Marino Silvia, La Spina Milena, Scuderi Maria Grazia, Di Benedetto Vincenzo, Magro Gaetano, Belfiore Giuseppe, Coronella Maria, D'Amico Salvatore, Lo Nigro Luca, Russo Giovanna, Di Cataldo Andrea
a Unit of Pediatric Hematology and Oncology , Department of Clinical and Experimental Medicine , Hospital Policlinico, University of Catania , Catania , Italy.
b Unit of Pediatric Surgery , Department GF Ingrassia , Hospital Policlinico, University of Catania , Catania , Italy.
Pediatr Hematol Oncol. 2016 May;33(4):259-63. doi: 10.3109/08880018.2016.1160169.
The treatment of neuroblastoma is based on the International Neuroblastoma Risk Group stratification considering life-threatening symptoms, image-defined risk factors (IDRFs), presence and site of metastases, biology, and histopathology. The authors present an infant with bilateral nonmetastatic adrenal neuroblastoma with favorable biology. Both tumors were resectable and without IDRFs, but bilateral resection was considered mutilating, so it was decided to operate one side only. The authors suggest considering bilaterality among IDRFs.
神经母细胞瘤的治疗基于国际神经母细胞瘤风险组分层，考虑危及生命的症状、影像定义的风险因素（IDRFs）、转移灶的存在及部位、生物学特性和组织病理学。作者报告了一名患有双侧非转移性肾上腺神经母细胞瘤且生物学特性良好的婴儿。两个肿瘤均可切除且无IDRFs，但双侧切除被认为是致残性的，因此决定仅对一侧进行手术。作者建议将双侧性纳入IDRFs之中。
