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[血液透析患者抗氧化稳态的变化]

[Changes in anti-oxidative homeostasis in hemodialysis patients].

作者信息

Schmidtmann S, Popov I, Precht K, von Baehr R

机构信息

Klinik für Innere Medizin, Bereiches Medizin (Charité) der Humboldt-Universität zu Berlin.

出版信息

Z Urol Nephrol. 1989 Feb;82(2):77-80.

PMID:2728633
Abstract

Changes of the antioxidative homoeostasis in hemodialysis patients were registered by determination of the antioxidative capacity (AC). This capacity has been increased before dialysis and decreased by 50% during dialysis. After 30 minutes of dialysis the AC was much more decreased than creatinine and urea. The cause of this AC reduction is not only a loss of antioxidants into the dialysate, but possibly also an oxygen radical formation by C5a-activated granulocytes, sequestered in pulmonary capillaries during transient leucopenia.

摘要

通过测定抗氧化能力(AC)来记录血液透析患者抗氧化稳态的变化。这种能力在透析前有所增加,而在透析过程中下降了50%。透析30分钟后,AC的下降幅度远大于肌酐和尿素。AC降低的原因不仅是抗氧化剂进入透析液中流失,还可能是在短暂白细胞减少期间,C5a激活的粒细胞在肺毛细血管中隔离导致氧自由基形成。

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