γ-麦角甾醇A、B和γ-麦角甾醇，来自于鸭茅上的叶黑粉菌子座的新型抗真菌化合物。

Gamahonolides A, B, and Gamahorin, Novel Antifungal Compounds from Stromata of Epichloe typhina on Phleum pratense.

作者信息

Koshino H, Yoshihara T, Okuno M, Sakamura S, Tajimi A, Shimanuki T

机构信息

a Department of Agricultural Chemistry, Faculty of Agriculture , Hokkaido University , Sapporo 060 , Japan.

b Hokkaido National Agricultural Experiment Station , Sapporo 060-01 , Japan.

出版信息

Biosci Biotechnol Biochem. 1992 Jan;56(7):1096-9. doi: 10.1271/bbb.56.1096.

DOI:10.1271/bbb.56.1096

PMID:27286384

Abstract

Four novel antifungal compounds, gamahonolides A and B, gamahorin, and 5-hydroxyl-4-phenyl-2(5H)-furanone, were isolated from stromata of Epichloe typhina on Phleum pratense. Their structures were determined by spectroscopic methods. The absolute configuration of gamahonolide A was determined by its ORD spectrum and (1)H-NMR shift difference between the diastereomeric pair of its O-methylmandelates. The stereochemistry of gamahorin was determined by NOE difference spectra and its CD spectrum.

摘要

从生长在猫尾草上的叶黑粉菌子座中分离出了四种新型抗真菌化合物，即γ-霍诺内酯A和B、γ-霍诺林以及5-羟基-4-苯基-2(5H)-呋喃酮。通过光谱方法确定了它们的结构。γ-霍诺内酯A的绝对构型通过其ORD光谱以及其O-甲基扁桃酸非对映体对之间的(1)H-NMR位移差异来确定。γ-霍诺林的立体化学通过NOE差异光谱及其CD光谱来确定。