[Clinico-immunologic parallels in multiple sclerosis].

HLA antigens were compared in groups of patients with disseminated sclerosis and healthy donors. In remission group as compared with controls, increased were the rates of A9, B7, B13, B35, A0/B17, A1/B7, A9/B7, A3/B35, A11/B7, A11/B8, B5, B7, 15, and in the progredient group--B7, Bw22, B35, A1/B7, A2/B7, A2/B35, A9/B7, B7, 12. These groups were different only in A11/B7 rates. Remitting and progredient course of the disease in women differed in A3 and A10 rates, in men in A2 and A11. In men with remitting course the A2 antigen rate was substantially lower than in any other group. With respect to the disease duration and the degree of patients's invalidization, the groups of benign, malignant, and intermediate course were singled out differing from each other and controls also in their HLA composition.