[圆锥角膜患者淋巴细胞的免疫遗传学分型结果]

[Results of immunogenetic typing of lymphocytes of patients with keratoconus].

作者信息

Gorskova E N, Tarasova L N, Teplova S N, Sevost'ianov E N

出版信息

Vestn Oftalmol. 1998 Mar-Apr;114(2):50-2.

Abstract

Histotyping of HLA I antigens in 100 patients with keratoconus. Europeoids of the Chelyabinsk district, and of 701 controls (donors listed in the regional register) showed an increased incidence of HLA A28, B12, and B15, a decreased incidence of HLA B8, B13, and complete absence of HLA A11. Estimation of HLA haplotypes in keratoconus showed an increased incidence of haplotypes A1-B5 (relative risk RR = 5.9), A2-B15 (RR = 3.34), A2-B27 (RR = 2.12), and A9-B21 (RR = 4.13) and decreased incidence of A1-B8 (RR = 0.31). The incidence of incomplete phenotypes was 27%. The most incident of incomplete phenotypes was A3-B35. Reliably linked HLA haplotypes A3-B7, A2-B27, A9-B21, and A9-B35 were typical of men with keratoconus, whereas A2-B21 haplotype was characteristic of the female patients.

摘要

100例圆锥角膜患者、车里雅宾斯克地区的欧罗巴人种以及701名对照者（地区登记册中的供体）的HLA I类抗原组织分型显示，HLA A28、B12和B15的发生率增加，HLA B8、B13的发生率降低，且完全不存在HLA A11。圆锥角膜患者HLA单倍型的评估显示，单倍型A1-B5（相对风险RR = 5.9）、A2-B15（RR = 3.34）、A2-B27（RR = 2.12）和A9-B21（RR = 4.13）的发生率增加，而A1-B8（RR = 0.31）的发生率降低。不完全表型的发生率为27%。最常见的不完全表型是A3-B35。与圆锥角膜男性患者相关的可靠HLA单倍型是A3-B7、A2-B27、A9-B21和A9-B35，而A2-B21单倍型是女性患者的特征。