Prokof'ev V F, Gribacheva I A, Konenkov V I, Doronin B M, Voronova I A
Zh Nevropatol Psikhiatr Im S S Korsakova. 1988;88(12):49-52.
The contents of class 1 HLA antigens was compared in patients with disseminated sclerosis, their first-grade relatives and healthy donors. Patients, as compared to healthy persons, had higher occurrence rate of A1, A9, B7, A0/B0, A9/B7, A1/B7, A1/B12, A2/B7, B7, 27, B5, 0, B7, 12, B7, 15, B5, 7, and lower A28, B13, Bw22, B35, 40, B7, 35, A2, w19, A0/B35, A0/B13, A2/B15, A3/B35. In male patients, as compared to female patients, B40 and A1/B15 were more frequent, and B12 less frequent. The subgroup of patients with the diseases onset before 20 years considerably differed from other patients in their rates of A1, A1, 2, A1w19, A1/B0 increased and A3 and A9/B17 decreased. Compared to donor group, the patients' relatives had differences similar to those between patients and relatives. High relative risk values were characteristic of some of the above associations.
对患有播散性硬化症的患者、其一级亲属和健康供体的1类HLA抗原含量进行了比较。与健康人相比，患者中A1、A9、B7、A0/B0、A9/B7、A1/B7、A1/B12、A2/B7、B7、27、B5、0、B7、12、B7、15、B5、7的出现率较高，而A28、B13、Bw22、B35、40、B7、35、A2、w19、A0/B35、A0/B13、A2/B15、A3/B35的出现率较低。在男性患者中，与女性患者相比，B40和A1/B15更为常见，而B12则较少见。疾病发病年龄在20岁之前的患者亚组在A1、A1、2、A1w19、A1/B0的发生率增加以及A3和A9/B17的发生率降低方面与其他患者有很大差异。与供体组相比，患者亲属的差异与患者和亲属之间的差异相似。上述一些关联具有较高的相对风险值特征。
