Li Ziyu, Shan Fei, Wang Yinkui, Li Shuangxi, Jia Yongning, Zhang Lianhai, Yin Daoxin, Ji Jiafu
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital & Institute, 52 Fucheng Road, Haidian District, Beijing, 100142, China.
George Warren Brown School, Washington University in Saint Louis, One Brookings Drive, St. Louis, 63130, MO, USA.
Surg Endosc. 2016 Oct;30(10):4265-71. doi: 10.1007/s00464-015-4739-z. Epub 2016 Jun 10.
To compare the safety and efficacy of laparoscopic distal gastrectomy (LDG) versus open distal gastrectomy (ODG) in treating locally advanced distal gastric cancer after neoadjuvant chemotherapy (NACT).
Forty-four patients with locally advanced distal gastric cancer were enrolled. The patients received neoadjuvant chemotherapy before undergoing surgery. Twenty patients were allocated into LDG after NACT group and 24 patients into ODG after NACT group. Radicalness of oncological resection, surgical safety and recovery were measured and compared.
All operations were successfully performed without severe postoperative complications. There were no significant differences in blood loss, mean operation time, complications, distal and proximal resection margin, and number of retrieved lymph nodes between LDG and ODG groups, but LDG group had shorter length of incision and the first aerofluxus time.
Laparoscopic distal gastrectomy after NACT has comparable results with open distal gastrectomy in safety and efficacy in the short term.
比较新辅助化疗（NACT）后腹腔镜远端胃癌切除术（LDG）与开放远端胃癌切除术（ODG）治疗局部进展期远端胃癌的安全性和疗效。
纳入44例局部进展期远端胃癌患者。患者在手术前行新辅助化疗。20例患者被分配至NACT后LDG组，24例患者被分配至NACT后ODG组。测量并比较肿瘤切除的根治性、手术安全性和恢复情况。
所有手术均成功完成，术后无严重并发症。LDG组与ODG组在失血量、平均手术时间、并发症、远端和近端切缘以及清扫淋巴结数量方面无显著差异，但LDG组切口长度和首次排气时间较短。
NACT后腹腔镜远端胃癌切除术在短期安全性和疗效方面与开放远端胃癌切除术相当。
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