Pillai Vivek, Roth Thomas, Drake Christopher L
Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI, United States.
Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI, United States.
Sleep Med. 2016 Oct;26:62-68. doi: 10.1016/j.sleep.2016.01.013. Epub 2016 Feb 13.
Although sleep symptoms of insomnia can be quantified, none of the current diagnostic systems stipulate quantitative cutoffs for sleep-onset latency (SOL) or wake time after sleep onset (WASO). Diagnoses are based instead on idiographic patient reports of "difficulty" falling/staying asleep. Therefore, we examined whether remission of insomnia as per the diagnostic criteria results from a normalization of quantitative sleep disturbance, or if it is simply reflective of tolerance to sleep symptoms.
This study involved a yearlong prospective investigation of 649 adults (48.1 ± 11.6 years; 69.3% female) with DSM-5-based insomnia. Participants completed measures of sleep disturbance, perceived sleep-related distress, daytime sleepiness, functional impairment, and workplace productivity at baseline and follow-up one year later.
A total of 271 participants no longer met the DSM-5-based insomnia criteria at follow-up. However, 66% of these remitters reported ≥31 min of SOL and/or WASO. Daytime impairment in this subgroup of remitters was no different from that among individuals who met the diagnostic criteria at both baseline and follow-up (ie, chronic insomniacs). By contrast, follow-up impairment was significantly lower (F = 12.3; P < 0.01) among remitters whose sleep disturbance returned below empirically derived quantitative cutoffs (both SOL and WASO <31 min) than in chronic insomniacs.
This is the first study on the long-term course of insomnia based on the newly established DSM-5 criteria. A troubling implication of findings is that a majority of insomniacs stop meeting the diagnostic criteria despite continued sleep disturbance and impairment. "Remission" in these cases is attributable instead to tolerance of sleep symptoms. Incorporating quantitative criteria into current diagnoses may offer a more sensitive assay of treatment needs.
尽管失眠的睡眠症状可以量化,但目前的诊断系统均未规定入睡潜伏期(SOL)或睡眠中觉醒时间(WASO)的定量临界值。相反,诊断是基于患者关于入睡/维持睡眠“困难”的个体化报告。因此,我们研究了根据诊断标准的失眠缓解是源于定量睡眠障碍的正常化,还是仅仅反映了对睡眠症状的耐受。
本研究对649名基于《精神疾病诊断与统计手册》第5版(DSM-5)诊断为失眠的成年人(48.1±11.6岁;69.3%为女性)进行了为期一年的前瞻性调查。参与者在基线和一年后的随访时完成了睡眠障碍、感知到的与睡眠相关的痛苦、日间嗜睡、功能损害和工作场所生产力的测量。
共有271名参与者在随访时不再符合基于DSM-5的失眠标准。然而,这些缓解者中有66%报告SOL和/或WASO≥31分钟。该缓解者亚组的日间损害与在基线和随访时均符合诊断标准的个体(即慢性失眠症患者)无差异。相比之下,睡眠障碍恢复到根据经验得出的定量临界值以下(SOL和WASO均<31分钟)的缓解者的随访损害显著低于慢性失眠症患者(F = 12.3;P < 0.01)。
这是第一项基于新制定的DSM-5标准对失眠长期病程进行的研究。研究结果的一个令人不安的含义是,大多数失眠症患者尽管持续存在睡眠障碍和损害,但不再符合诊断标准。这些情况下的“缓解”反而归因于对睡眠症状的耐受。将定量标准纳入当前诊断可能会提供更敏感的治疗需求分析。