Kathopoulis Nikolaos, Thomakos Nikolaos, Mole Ioanna, Papaspirou Irene, Ntai Sparti, Rodolakis Alexandros
Department of Obstetrics and Gynecology, University of Athens School of Medicine, Alexandra Hospital, Athens, Greece.
Department of Obstetrics and Gynecology, University of Athens School of Medicine, Alexandra Hospital, Athens, Greece.
Int J Surg Case Rep. 2016;25:13-5. doi: 10.1016/j.ijscr.2016.05.022. Epub 2016 Jun 1.
Bladder exstrophy is a very rare congenital anomaly and is associated with an increased incidence of bladder cancer. Most patients undergo reconstructive operations during childhood.
A 53 year-old woman was diagnosed with enteric type mucinous adenocarcinoma of the unreconstructed exstrophic bladder. Preoperative examination revealed no primary site in the gastrointestinal system. The patient underwent an anterior pelvic exenteration with bilateral ureterostomy and repairing of the anterior abdominal wall defect with a mesh.
Carcinoma of the exstrophic bladder is a very rare entity. An overall number of 118 cases of cancer in unreconstructed bladder have been reported in the literature since 1895 with adenocarcinomas consisting of 90-91% and squamous cell carcinomas 8.5%. Mechanical irritation on the bladder mucosa, embryologic origin and urine carcinogens are some o the theories of cancerous metaplasia.
This is the first case of bladder exstrophy cancer reported that was submitted to anterior pelvic exenteration. We propose this surgical procedure as an appropriate alternative in postmenopausal women and cancer of the unreconstructed bladder exstrophy.
膀胱外翻是一种非常罕见的先天性畸形，且与膀胱癌发病率增加相关。大多数患者在儿童期接受重建手术。
一名53岁女性被诊断为未重建的外翻膀胱的肠型黏液腺癌。术前检查未发现胃肠道系统的原发部位。该患者接受了前盆腔脏器清除术及双侧输尿管造口术，并用网片修复前腹壁缺损。
外翻膀胱的癌是一种非常罕见的实体。自1895年以来，文献报道了118例未重建膀胱的癌症病例，其中腺癌占90 - 91%，鳞状细胞癌占8.5%。膀胱黏膜的机械刺激、胚胎起源和尿液致癌物是癌化生的一些理论。
这是首例报道的接受前盆腔脏器清除术的膀胱外翻癌病例。我们建议将这种手术方法作为绝经后女性未重建膀胱外翻癌的一种合适替代方案。
