Zendjabil M, Abbou O, Chellouai Z
Laboratoire de biochimie, établissement hospitalier universitaire d'Oran 1(er) Novembre 1954, BP 4166, Ibn Rochd, Oran, Algérie.
Laboratoire de biochimie, établissement hospitalier universitaire d'Oran 1(er) Novembre 1954, BP 4166, Ibn Rochd, Oran, Algérie.
Ann Pharm Fr. 2017 Jan;75(1):54-58. doi: 10.1016/j.pharma.2016.05.001. Epub 2016 Jun 8.
Metabolic syndrome (MS) is a phenomenon of insulin resistance, a harbinger of serious cardiovascular events. The lifestyle of Algerian becoming increasingly occidental, SM becomes a major problem of public health in our country. Furthermore, hyperhomocysteinemia is also recognized as a cardiovascular risk factor. The objective of this study was to determine the prevalence of hyperhomocysteinemia in patients with SM in our people and to seek a possible relationship between these two risk factors.
We performed a prospective study that was focused on 62 hospitalized patients with SM, composed of 33 men and 29 women. Clinical data were collected and laboratory tests were also performed.
The average age of our patients was 52±20 years; the average waist circumference was 103.4±10.1cm in men and 91.5±8.42cm in women. In this study, 53.2%, 54.4%, 25.8% and 51.6% of patients had respectively hypertension, hyperglycemia, low HDL-C levels and hypertriglyceridemia. The prevalence of hyperhomocysteinemia was 62.9% in our patients. This prevalence is correlated with age and the number of the SM components. Multivariate linear regression analysis showed no significant association between hyperhomocysteinemia and SM components studied separately.
The prevalence of hyperhomocysteinemia in patients with an SM is important in our population. It increases with age and number of SM components, without a relationship between hyperhomocysteinemia and SM components studied separately.
代谢综合征（MS）是一种胰岛素抵抗现象，是严重心血管事件的先兆。阿尔及利亚人的生活方式日益西化，代谢综合征已成为我国公共卫生的一个主要问题。此外，高同型半胱氨酸血症也被认为是一种心血管危险因素。本研究的目的是确定我国代谢综合征患者中高同型半胱氨酸血症的患病率，并探寻这两种危险因素之间可能存在的关系。
我们进行了一项前瞻性研究，该研究聚焦于62例住院的代谢综合征患者，其中男性33例，女性29例。收集了临床数据并进行了实验室检查。
我们患者的平均年龄为52±20岁；男性平均腰围为103.4±10.1厘米，女性为91.5±8.42厘米。在本研究中，53.2%、54.4%、25.8%和51.6%的患者分别患有高血压、高血糖、低高密度脂蛋白胆固醇水平和高甘油三酯血症。我们患者中高同型半胱氨酸血症的患病率为62.9%。这一患病率与年龄和代谢综合征的组成成分数量相关。多变量线性回归分析显示，高同型半胱氨酸血症与单独研究的代谢综合征组成成分之间无显著关联。
在我国人群中，代谢综合征患者中高同型半胱氨酸血症的患病率较高。它随年龄和代谢综合征组成成分数量的增加而升高，且高同型半胱氨酸血症与单独研究的代谢综合征组成成分之间无关联。
