Beaman Kenneth D, Jaiswal Mukesh K, Katara Gajendra K, Kulshreshta Arpita, Pamarthy Sahithi, Ibrahim Safaa, Kwak-Kim Joanne, Gilman-Sachs Alice
Clinical Immunology Laboratory, Department of Microbiology and Immunology, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.
Am J Reprod Immunol. 2016 Jul;76(1):3-7. doi: 10.1111/aji.12524.
Nearly 65 years have passed since Peter Medawar posed the following question: "How does the pregnant mother contrive to nourish within itself, for many weeks or months, a fetus that is an antigenically foreign body." Now, understanding of reproductive immunology has demonstrated that the HLA antigens in the placenta are non-classical and do not induce rejection. In the placenta and in tumors, 50% or more of the cells are cells of the immune system and were once thought to be primed and ready for killing tumors or the "fetal transplant" but these cells are not potential killers but abet the growth of either the tumor or the placenta. We believe that these cells are there to create an environment, which enhances either placental or tumor growth. By examining the similarities of the placenta's and tumor's immune cells, novel mechanisms to cause tumors to be eliminated can be devised.
自彼得·梅达沃提出以下问题以来，已经过去了近65年：“怀孕的母亲是如何在数周或数月的时间里，在自己体内滋养一个抗原性异物——胎儿的。”如今，对生殖免疫学的理解表明，胎盘中的人类白细胞抗原（HLA）是非经典的，不会引发排斥反应。在胎盘和肿瘤中，50%或更多的细胞是免疫系统的细胞，它们曾被认为已做好准备，随时可以杀死肿瘤或“胎儿移植物”，但这些细胞并非潜在的杀手，而是促进肿瘤或胎盘的生长。我们认为，这些细胞的存在是为了创造一个促进胎盘或肿瘤生长的环境。通过研究胎盘和肿瘤免疫细胞的相似性，可以设计出消除肿瘤的新机制。
