Langasco Rita, Spada Gianpiera, Tanriverdi Sakine Tuncay, Rassu Giovanna, Giunchedi Paolo, Özer Özgen, Gavini Elisabetta
Department of Chemistry and Pharmacy, University of Sassari, Sassari, Italy.
Biocosmesi, Sedilo, Italy.
J Pharm Pharmacol. 2016 Aug;68(8):999-1009. doi: 10.1111/jphp.12582. Epub 2016 Jun 12.
New salicylic acid (SA)-loaded gels were developed using excipients made from renewable materials, and our goal was to improve drug permeation in the topical treatment of acne vulgaris.
We studied the preparation parameters to obtain suitable gel formulations. Only naturally occurring polymers were used as gelling agents. Two hydrogels and three lipogels were selected and characterized in terms of drug loading, pH, viability cells, rheology, mechanical properties and in vitro permeation; these hydrogels and lipogels were compared with the traditional ointment. We also evaluated skin parameters before and after gel application.
The formulations that we studied are non-Newtonian fluids; they have high drug loading and suitable mechanical properties. Lipogels exhibit a slower and more linear in vitro permeation profile compared with hydrogels. The different vehicles that we used affected drug permeation and improve patient compliance. Cytotoxicity studies suggest that all of the formulations are non-toxic.
Lipogels demonstrate appropriate technological features and improved performance compared with the traditional ointment with regard to their composition. Lipogels may represent a new bio-based topical system for SA delivery. The use of 'green' excipients leads to 'skin-friendly' formulations that are able to satisfy environmental safety.
使用可再生材料制成的辅料开发了新型载水杨酸（SA）凝胶，我们的目标是在寻常痤疮的局部治疗中提高药物渗透性。
我们研究了制备参数以获得合适的凝胶制剂。仅使用天然存在的聚合物作为胶凝剂。选择了两种水凝胶和三种脂质凝胶，并在载药量、pH值、细胞活力、流变学、机械性能和体外渗透方面进行了表征；将这些水凝胶和脂质凝胶与传统软膏进行了比较。我们还评估了凝胶应用前后的皮肤参数。
我们研究的制剂是非牛顿流体；它们具有高载药量和合适的机械性能。与水凝胶相比，脂质凝胶在体外表现出更缓慢、更线性的渗透曲线。我们使用的不同载体影响药物渗透并提高患者依从性。细胞毒性研究表明所有制剂均无毒。
脂质凝胶在组成方面与传统软膏相比具有适当的技术特性和更好的性能。脂质凝胶可能代表一种新型的基于生物的SA递送局部系统。使用“绿色”辅料可得到“皮肤友好型”制剂，能够满足环境安全性要求。
