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多发性家族性毛发上皮瘤伴鳞状细胞癌的十二年观察

Twelve Years' Observation of Multiple Familial Trichoepithelioma with Squamous Carcinoma.

作者信息

Ma Huifu, Feng Song, Pei Wenjun, Jin Feng

机构信息

Department of Neurosurgery, Affiliated Hospital of Jining Medical College, Jining, Shandong, PR China.

Department of Pathology, Tuha Petroleum Hospital, Hami, Sinkiang, PR China.

出版信息

Indian J Dermatol. 2016 May-Jun;61(3):348. doi: 10.4103/0019-5154.182464.

DOI:10.4103/0019-5154.182464
PMID:27293274
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4885207/
Abstract

Long-standing trichoepithelioma lesion on scalp with 12 years follow-up. The patient was observed for 12 years, and the carcinoma recurred 3 times during 8 years after surgical excision and radiation therapy. Malignant transformation may occur in multiple familial trichoepitheliomas; Moderate radiation therapy should be given for malignant transformation patients with lower radiation dose and shorter time. Removing the trichoepithelioma as soon as possible if the tumor suddenly or continuously increased is recommended.

摘要

头皮长期存在的毛发上皮瘤病变，随访12年。对该患者进行了12年的观察，在手术切除和放射治疗后的8年中，肿瘤复发了3次。多发性家族性毛发上皮瘤可能发生恶变；对于恶变患者，应给予适度放疗，降低放疗剂量并缩短放疗时间。如果肿瘤突然或持续增大，建议尽快切除毛发上皮瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4027/4885207/983a3eb8c8b9/IJD-61-348a-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4027/4885207/2ab1cfbe11c0/IJD-61-348a-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4027/4885207/f30cc821a77e/IJD-61-348a-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4027/4885207/d9158e608b9b/IJD-61-348a-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4027/4885207/aecc0d54cf54/IJD-61-348a-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4027/4885207/f1164eda1e86/IJD-61-348a-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4027/4885207/33f96e5e79e0/IJD-61-348a-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4027/4885207/86ac366b74e0/IJD-61-348a-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4027/4885207/235735ea174a/IJD-61-348a-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4027/4885207/983a3eb8c8b9/IJD-61-348a-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4027/4885207/2ab1cfbe11c0/IJD-61-348a-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4027/4885207/f30cc821a77e/IJD-61-348a-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4027/4885207/d9158e608b9b/IJD-61-348a-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4027/4885207/aecc0d54cf54/IJD-61-348a-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4027/4885207/f1164eda1e86/IJD-61-348a-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4027/4885207/33f96e5e79e0/IJD-61-348a-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4027/4885207/86ac366b74e0/IJD-61-348a-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4027/4885207/235735ea174a/IJD-61-348a-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4027/4885207/983a3eb8c8b9/IJD-61-348a-g009.jpg

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本文引用的文献

1
Multiple familial trichoepithelioma with malignant transformation.伴恶性转化的多发性家族性毛发上皮瘤
Indian J Dermatol. 2013 Sep;58(5):409. doi: 10.4103/0019-5154.117348.
2
Multiple familial trichoepitheliomas in association with squamous cell carcinoma.多发性家族性毛发上皮瘤伴鳞状细胞癌
Indian Dermatol Online J. 2012 May;3(2):151-3. doi: 10.4103/2229-5178.96726.
3
Malignant transformation of multiple familial trichoepithelioma: case report and literature review.多发性家族性毛发上皮瘤的恶性转化：病例报告及文献复习
Acta Derm Venereol. 2008;88(1):43-6. doi: 10.2340/00015555-0322.
4
Mutations in the CYLD gene in Brooke-Spiegler syndrome, familial cylindromatosis, and multiple familial trichoepithelioma: lack of genotype-phenotype correlation.布鲁克-施皮格勒综合征、家族性圆柱瘤病和多发性家族性毛发上皮瘤中CYLD基因的突变：基因型与表型缺乏相关性。
J Invest Dermatol. 2005 May;124(5):919-20. doi: 10.1111/j.0022-202X.2005.23688.x.
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High-grade trichoblastic carcinoma arising in trichoblastoma: a rare adnexal neoplasm often showing metastatic spread.起源于毛母细胞瘤的高级别毛母细胞癌：一种罕见的附属器肿瘤，常发生转移扩散。
Am J Dermatopathol. 2005 Feb;27(1):9-16. doi: 10.1097/01.dad.0000142240.93956.cb.
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CYLD mutation causes multiple familial trichoepithelioma in three Chinese families.CYLD突变在三个中国家系中导致多发性家族性毛发上皮瘤。
Hum Mutat. 2004 Apr;23(4):400. doi: 10.1002/humu.9231.
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Trichilemmal carcinoma in an African American.一名非裔美国人患外毛根鞘癌。
Dermatol Surg. 2002 Mar;28(3):284-6. doi: 10.1046/j.1524-4725.2002.01128.x.
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Trichoblastic carcinoma ("malignant trichoblastoma") with lymphatic and hematogenous metastases.具有淋巴道和血行转移的毛母质癌（“恶性毛母细胞瘤”）
Mod Pathol. 2000 Jun;13(6):673-8. doi: 10.1038/modpathol.3880118.
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An unusually aggressive trichoblastoma.一种异常侵袭性的毛发母细胞瘤。
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Malignant hair matrix tumor ("malignant trichoepithelioma") arising in the setting of multiple hereditary trichoepithelioma.多发性遗传性毛发上皮瘤背景下发生的恶性毛母质瘤（“恶性毛发上皮瘤”）
Am J Dermatopathol. 1991 Jun;13(3):275-81. doi: 10.1097/00000372-199106000-00010.