Haverkampf Sonja, Evert Katja, Schröder Josef, Schreml Stephan
Department of Dermatology, University Medical Center Regensburg, Germany.
Institute of Pathology, University of Regensburg, Regensburg, Germany.
Case Rep Dermatol. 2016 Feb 3;8(1):22-5. doi: 10.1159/000443950. eCollection 2016 Jan-Apr.
A 79-year-old man presented with a large tumor on the left side of his head, which had grown over 5 years. Regional lymph nodes were impalpable and computed tomography revealed no signs of bone infiltration. Histology showed that the entire dermis was filled with amorphous eosinophilic material. Immunohistochemistry was negative for cytokeratin, but showed that the dermis and parts of the subcutis were filled with amyloid consisting of immunoglobulin light chains. There were no signs of paraproteinemia or underlying plasmocytoma. In electron microscopy, the typical amyloid fibrils were found. The tumor was completely removed via curettage. At 1-year follow-up, the patient was doing fine with no signs of relapse or systemic disease.
一名79岁男性患者头部左侧出现一个巨大肿瘤，已生长5年。区域淋巴结未触及，计算机断层扫描未显示骨浸润迹象。组织学检查显示整个真皮充满无定形嗜酸性物质。免疫组织化学检查细胞角蛋白呈阴性，但显示真皮和部分皮下组织充满由免疫球蛋白轻链组成的淀粉样蛋白。无副蛋白血症或潜在浆细胞瘤的迹象。电子显微镜检查发现了典型的淀粉样纤维。通过刮除术将肿瘤完全切除。随访1年时，患者情况良好，无复发或全身疾病迹象。
