警报能否提高骨质疏松症患者每周双膦酸盐治疗的依从性？
Can Alarming Improve Compliance with Weekly Bisphosphonate in Patients with Osteoporosis?
作者信息
Nho Jae-Hwi, Lee Young-Kyun, Ha Yong-Chan, Kim Chung-Hyun, Suh You-Sung, Koo Kyung-Hoi
机构信息
Department of Orthopaedic Surgery, Soonchunhyang University Hospital Seoul, Seoul, Korea.
Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
出版信息
J Bone Metab. 2016 May;23(2):51-4. doi: 10.11005/jbm.2016.23.2.51. Epub 2016 May 31.
BACKGROUND
Although bisphosphonate is effective for the prevention and treatment of osteoporosis, poor medication compliance is a key-limiting factor. We determined whether alarm clock could improve compliance with weekly bisphosphonate in patients with osteoporosis, by comparing with age- and gender-matched control group.
METHODS
Fifty patients with osteoporosis were recruited and participated in alarm clock group. Patients were asked to take orally weekly risedronate for 1 year, and received alarm clock to inform the time of taking oral bisphosphonate weekly. Using the propensity score matching with age and gender, 50 patients were identified from patients with osteoporosis medication. We compared the compliance with bisphosphonate using medication possession ratio (MPR) between two groups.
RESULTS
Although there was no significant difference of baseline characteristics between both groups, the mean MPR (0.80±0.33) of alarm clock group was higher than that (0.56±0.34) of control group (P<0.001).
CONCLUSIONS
Alarming could improve the compliance with weekly oral bisphosphonate in patients with osteoporosis.
背景
尽管双膦酸盐对骨质疏松症的预防和治疗有效，但用药依从性差是一个关键限制因素。我们通过与年龄和性别匹配的对照组比较，确定闹钟是否能提高骨质疏松症患者每周服用双膦酸盐的依从性。
方法
招募50例骨质疏松症患者并纳入闹钟组。患者被要求每周口服利塞膦酸钠1年，并使用闹钟告知每周口服双膦酸盐的时间。通过倾向得分匹配年龄和性别，从骨质疏松症用药患者中确定50例患者作为对照组。我们使用药物持有率（MPR）比较两组患者双膦酸盐的依从性。
结果
尽管两组患者的基线特征无显著差异，但闹钟组的平均MPR（0.80±0.33）高于对照组（0.56±0.34）（P<0.001）。
结论
闹钟提示可提高骨质疏松症患者每周口服双膦酸盐的依从性。
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