Hong Jin Yong, Sunwoo Mun Kyung, Oh Jungsu S, Kim Jae Seung, Sohn Young H, Lee Phil Hyu
Department of Neurology, Yonsei University Wonju College of Medicine, Wonju, Korea.
Department of Neurology, Bundang Jesaeng General Hospital, Seongnam, Korea.
PLoS One. 2016 Jun 13;11(6):e0157410. doi: 10.1371/journal.pone.0157410. eCollection 2016.
Functional neuroimaging for the dopamine transporter (DAT) is used to distinguish drug-induced parkinsonism (DIP) from subclinical Parkinson's disease (PD). Although DIP patients who show a normal DAT image are expected to recover completely, some do not. We investigated whether these patients showed changes in striatal DAT activity using semi-quantitative analysis of 18F-FP-CIT PET data. DIP patients with visually normal DAT images were selected from medical records. The subjects were classified as patients who recovered partially (PR) or completely within 12 months (CR). The 18F-FP-CIT uptake in each striatal subregion was compared between the CR and the PR groups. In total, 41 and 9 patients of the CR and PR groups were assessed, respectively. The two patient groups were comparable in terms of clinical characteristics including age, sex, and severity of parkinsonism. From semi-quantitative analysis of the PET image, the PR patients showed a relatively lower ligand uptake in the ventral striatum, the anterior putamen and the posterior putamen compared with the CR patients. This result suggests that persistent DIP in patients with visually normal DAT imaging may be associated with subtle decrement of DAT activity.
用于多巴胺转运体（DAT）的功能神经成像可用于区分药物性帕金森综合征（DIP）和亚临床帕金森病（PD）。尽管预计DAT图像正常的DIP患者可完全康复，但仍有部分患者无法完全康复。我们通过对18F-FP-CIT PET数据进行半定量分析，研究了这些患者纹状体DAT活性是否发生变化。从病历中选取DAT图像视觉上正常的DIP患者。将受试者分为在12个月内部分恢复（PR）或完全恢复（CR）的患者。比较了CR组和PR组各纹状体亚区域的18F-FP-CIT摄取情况。CR组和PR组分别评估了41例和9例患者。两组患者在年龄、性别和帕金森综合征严重程度等临床特征方面具有可比性。通过PET图像的半定量分析，与CR患者相比，PR患者在腹侧纹状体、前壳核和后壳核中的配体摄取相对较低。这一结果表明，DAT成像视觉上正常的患者中持续存在的DIP可能与DAT活性的细微降低有关。
