帕金森综合征患者早期使用F-FP-CIT PET/CT进行灌注和多巴胺转运体成像
Early perfusion and dopamine transporter imaging using F-FP-CIT PET/CT in patients with parkinsonism.
作者信息
Hong Chae-Moon, Ryu Ho-Sung, Ahn Byeong-Cheol
机构信息
Department of Nuclear Medicine, Kyungpook National University Hospital Daegu, Republic of Korea.
Department of Nuclear Medicine, School of Medicine, Kyungpook National University Daegu, Republic of Korea.
出版信息
Am J Nucl Med Mol Imaging. 2018 Dec 20;8(6):360-372. eCollection 2018.
Abstract
Combined use of F-N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl)nortropane (FP-CIT) for dopamine transporter imaging and F-fludeoxyglucose (FDG) for glucose metabolism shows good diagnostic performance for differential diagnosis of Parkinson disease (PD) and Parkinson plus syndrome (multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration, and dementia with Lewy bodies). A recent study showed that F-FP-CIT positron emission tomography (PET) with early perfusion imaging is useful for the differential diagnosis of PD and Parkinson plus syndrome with lower radiation exposure, time, and cost. In this review, we summarize the advantages of using F-FP-CIT PET for perfusion and dopamine transporter imaging, as well as clinical features useful for the differential diagnosis of PD and Parkinson plus syndrome.
摘要
联合使用F-N-(3-氟丙基)-2β-羧甲氧基-3β-(4-碘苯基)去甲托烷（FP-CIT）进行多巴胺转运体成像以及F-氟脱氧葡萄糖（FDG）进行葡萄糖代谢，在帕金森病（PD）和帕金森叠加综合征（多系统萎缩、进行性核上性麻痹、皮质基底节变性和路易体痴呆）的鉴别诊断中显示出良好的诊断性能。最近一项研究表明，早期灌注成像的F-FP-CIT正电子发射断层扫描（PET）在较低的辐射暴露、时间和成本下，对PD和帕金森叠加综合征的鉴别诊断有用。在本综述中，我们总结了使用F-FP-CIT PET进行灌注和多巴胺转运体成像的优势，以及对PD和帕金森叠加综合征鉴别诊断有用的临床特征。
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