转移抑制蛋白（S100A4）、钙粒蛋白A（S100A8）和钙粒蛋白B（S100A9）在口腔病变中的细胞分布及基因表达模式作为分子病理学标志物
Cellular Distribution and Gene Expression Pattern of Metastasin (S100A4), Calgranulin A (S100A8), and Calgranulin B (S100A9) in Oral Lesions as Markers for Molecular Pathology.
作者信息
Reckenbeil Jan, Kraus Dominik, Probstmeier Rainer, Allam Jean-Pierre, Novak Natalija, Frentzen Matthias, Martini Markus, Wenghoefer Matthias, Winter Jochen
机构信息
a Department of Periodontology, Operative and Preventive Dentistry , University of Bonn , Bonn , Germany.
b Department of Prosthodontics, Preclinical Education, and Material Science , University of Bonn , Bonn , Germany.
出版信息
Cancer Invest. 2016 Jul 2;34(6):246-54. doi: 10.1080/07357907.2016.1186172. Epub 2016 Jun 13.
The objective of this study was to analyze cellular localization and expression levels of oncologic relevant members of the S100 family in common oral lesions.Biopsies of various oral lesions were analyzed. S100A4 showed a higher expression rate in leukoplakias and oral squamous cell carcinomas. Transcript levels of S100A8 and S100A9 were significantly decreased in malignant OSCCs. A correlation could be drawn between the expression levels of these genes and the pathological characteristics of the investigated lesions. S100A4, A8, and A9 proteins represent promising marker genes to evaluate the risk potential of suspicious oral lesions in molecular pathology.
本研究的目的是分析S100家族肿瘤相关成员在常见口腔病变中的细胞定位和表达水平。对各种口腔病变的活检样本进行了分析。S100A4在白斑和口腔鳞状细胞癌中显示出较高的表达率。在恶性口腔鳞状细胞癌中，S100A8和S100A9的转录水平显著降低。这些基因的表达水平与所研究病变的病理特征之间存在相关性。S100A4、A8和A9蛋白是分子病理学中评估可疑口腔病变风险潜力的有前景的标记基因。
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