Vora Setu M, Phillips Bryan T
a Department of Biological Sciences, University of Iowa , Iowa City , IA , USA.
Cell Cycle. 2016 Aug 17;15(16):2124-2134. doi: 10.1080/15384101.2016.1196306. Epub 2016 Jun 13.
The centrosome is the major microtubule-organizing center in animal cells but is dispensable for proper microtubule spindle formation in many biological contexts and is thus thought to fulfill additional functions. Recent observations suggest that the centrosome acts as a scaffold for proteasomal degradation in the cell to regulate a variety of biological processes including cell fate acquisition, cell cycle control, stress response, and cell morphogenesis. Here, we review the body of studies indicating a role for the centrosome in promoting proteasomal degradation of ubiquitin-proteasome substrates and explore the functional relevance of this system in different biological contexts. We discuss a potential role for the centrosome in coordinating local degradation of proteasomal substrates, allowing cells to achieve stringent spatiotemporal control over various signaling processes.
中心体是动物细胞中主要的微管组织中心，但在许多生物学环境中对于正确的微管纺锤体形成并非必需，因此被认为具有其他功能。最近的观察表明，中心体在细胞中作为蛋白酶体降解的支架，以调节多种生物学过程，包括细胞命运获得、细胞周期控制、应激反应和细胞形态发生。在这里，我们综述了一系列表明中心体在促进泛素-蛋白酶体底物的蛋白酶体降解中发挥作用的研究，并探讨了该系统在不同生物学环境中的功能相关性。我们讨论了中心体在协调蛋白酶体底物的局部降解中的潜在作用，使细胞能够对各种信号传导过程实现严格的时空控制。
