Bruni Natascia, Capucchio Maria Teresa, Biasibetti Elena, Pessione Enrica, Cirrincione Simona, Giraudo Leonardo, Corona Antonio, Dosio Franco
Istituto Farmaceutico Candioli, Beinasco (To) 10092, Italy.
Department of Veterinary Sciences, University of Torino, Torino 10095, Italy.
Molecules. 2016 Jun 11;21(6):752. doi: 10.3390/molecules21060752.
Antimicrobial peptides (AMPs) represent a vast array of molecules produced by virtually all living organisms as natural barriers against infection. Among AMP sources, an interesting class regards the food-derived bioactive agents. The whey protein lactoferrin (Lf) is an iron-binding glycoprotein that plays a significant role in the innate immune system, and is considered as an important host defense molecule. In search for novel antimicrobial agents, Lf offers a new source with potential pharmaceutical applications. The Lf-derived peptides Lf(1-11), lactoferricin (Lfcin) and lactoferrampin exhibit interesting and more potent antimicrobial actions than intact protein. Particularly, Lfcin has demonstrated strong antibacterial, anti-fungal and antiparasitic activity with promising applications both in human and veterinary diseases (from ocular infections to osteo-articular, gastrointestinal and dermatological diseases).
抗菌肽（AMPs）是几乎所有生物产生的大量分子，作为抵御感染的天然屏障。在抗菌肽来源中，一类有趣的是食物衍生的生物活性剂。乳清蛋白乳铁蛋白（Lf）是一种铁结合糖蛋白，在先天免疫系统中发挥重要作用，被认为是一种重要的宿主防御分子。在寻找新型抗菌剂的过程中，Lf提供了一种具有潜在药物应用价值的新来源。源自Lf的肽Lf(1-11)、乳铁素（Lfcin）和乳铁杀菌肽表现出比完整蛋白质更有趣且更强效的抗菌作用。特别是，Lfcin已显示出强大的抗菌、抗真菌和抗寄生虫活性，在人类和兽医疾病（从眼部感染到骨关节、胃肠道和皮肤病）中都有应用前景。
