表皮生长因子、生长分化因子-15和生存素作为慢性透析儿童新型生物相容性标志物
Epidermal growth factor, growth differentiation factor-15, and survivin as novel biocompatibility markers in children on chronic dialysis.
作者信息
Bargenda Agnieszka, Musiał Kinga, Zwolińska Danuta
机构信息
a Department of Pediatric Nephrology , Wrocław Medical University , Wrocław , Poland.
出版信息
Biomarkers. 2016 Dec;21(8):752-756. doi: 10.1080/1354750X.2016.1201534. Epub 2016 Jun 24.
CONTEXT
Chronic dialysis results in aggravation of apoptosis and cell damage, triggered by bioincompatibility of dialysis membranes and peritoneal fluids.
OBJECTIVE
The aim of study was to assess the usefulness of epidermal growth factor (EGF), growth differentiation factor (GDF)-15, and survivin as novel markers of biocompatibility in dialyzed children.
MATERIALS AND METHODS
Parameters were assessed by ELISA in 19 patients on hemodialysis and 22 children on peritoneal dialysis.
RESULTS
Serum concentrations of analyzed parameters in children on chronic dialysis differed significantly from controls and depended strongly on the dialysis technique.
CONCLUSIONS
EGF, GDF-15, and survivin may serve as new biocompatibility markers in children on chronic dialysis.
背景
慢性透析会导致细胞凋亡和细胞损伤加剧，这是由透析膜和腹膜液的生物不相容性引发的。
目的
本研究的目的是评估表皮生长因子（EGF）、生长分化因子（GDF）-15和生存素作为透析儿童生物相容性新标志物的实用性。
材料与方法
通过酶联免疫吸附测定法（ELISA）对19例血液透析患者和22例腹膜透析儿童的参数进行评估。
结果
慢性透析儿童的分析参数血清浓度与对照组有显著差异，且强烈依赖于透析技术。
结论
EGF、GDF-15和生存素可能作为慢性透析儿童新的生物相容性标志物。
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