生长分化因子 15 和铁调素作为慢性肾脏病贫血的治疗靶点。
GDF-15 and hepcidin as a therapeutic target for anemia in chronic kidney disease.
机构信息
Clinical Pathology, Minia University, Minia, Egypt.
Pediatrics Dep., Minia University, Minia, Egypt.
出版信息
Ital J Pediatr. 2023 Aug 30;49(1):106. doi: 10.1186/s13052-023-01505-9.
BACKGROUND
Anaemia is a common presenting feature among patients with chronic kidney disease (CKD) and associated with poor clinical outcomes. We evaluated the diagnostic validity of growth differentiation factor-15 (GDF-15) and hepcidin as it is not clear if they are useful as a biomarkers of anaemia among non-dialysis CKD egyptian patients.
METHOD
An analytical cross-sectional study was conducted among non-dialysis CKD patients (n = 60) and apparently healthy controls (n = 28) at Minia University maternity & children Hospital. Serum levels of GDF-15 and hepcidin were determined. Predictive logistic regression models were built and post estimation receiver operator characteristics were determined to evaluate diagnostic validity of hepcidin and GDF-15 for iron deficiency anaemia.
RESULTS
Hepcidin and GDF-15 are significantly higher in cases than control p value (0.047 < 0.0001) respectively. The predictive value of diagnosing anaemia among CKD patients using hepcidin and GDF-15 was 72.0%, 70.0%. There was a weak negative correlation between hepcidin levels and glomerular filtration rate GFR (r = -.175, p = 0.105) in CKD patients, and significant correlation between serum GDF-15 and haemoglobin (r = -0.897, p < 0.0001), ferritin (r = 0.489, P < 0.000), Iron (r = -0.314, P = 0.002), CRP (r = 0.409, P < 0.0001).
CONCLUSION
Hepcidin and GDF-15 is a potential biomarker for predicting anaemia connected with inflammation among CKD Egyptian patients.
背景
贫血是慢性肾脏病（CKD）患者常见的临床表现，与不良临床结局相关。我们评估了生长分化因子 15（GDF-15）和铁调素的诊断有效性，因为尚不清楚它们是否可作为埃及非透析 CKD 患者贫血的生物标志物。
方法
在米尼亚大学妇产儿童医院进行了一项非透析 CKD 患者（n=60）和健康对照者（n=28）的分析性横断面研究。测定血清 GDF-15 和铁调素水平。建立预测性逻辑回归模型，并进行估计后接收者操作特征分析，以评估铁调素和 GDF-15 对缺铁性贫血的诊断价值。
结果
病例组铁调素和 GDF-15 水平明显高于对照组（p 值分别为 0.047 和<0.0001）。铁调素和 GDF-15 用于诊断 CKD 患者贫血的预测值分别为 72.0%和 70.0%。在 CKD 患者中，铁调素水平与肾小球滤过率（GFR）呈弱负相关（r=-0.175，p=0.105），与血红蛋白（r=-0.897，p<0.0001）、铁蛋白（r=0.489，p<0.0001）、铁（r=-0.314，p=0.002）、C 反应蛋白（r=0.409，p<0.0001）呈显著正相关。
结论
铁调素和 GDF-15 是预测埃及 CKD 患者与炎症相关贫血的潜在生物标志物。
Zotero 插件