Crogan S J, Bishop M J
Division of Respiratory Therapy, Harborview Medical Center, University of Washington School of Medicine 98104.
Anesthesiology. 1989 Jun;70(6):1008-10. doi: 10.1097/00000542-198906000-00021.
The authors studied the efficiency of delivery of the inhaled bronchodilator metaproterenol when delivered via an endotracheal tube (ETT) using a metered dose inhaler (MDI). They found that the percentage of drug exiting the ETT varied with tube size, ranging from 3.0 +/- 1.9 for a 6.0 mm ETT to 6.5 +/- 4.4 for a 9.0 mm ETT (mean +/- SEM, P less than 0.05). The efficiency of delivery was also affected by whether the MDI was activated before or after initiation of gas flow through the ETT, with activation into a flowing stream significantly more efficient. The authors conclude that an MDI can deliver a dose of drug to the trachea, but delivery efficiency is lower than reported for MDI delivery in spontaneously breathing patients.
作者研究了使用定量吸入器（MDI）经气管内导管（ETT）输送吸入性支气管扩张剂间羟异丙肾上腺素的效率。他们发现，药物从ETT出来的百分比随导管尺寸而变化，6.0毫米ETT为3.0±1.9，9.0毫米ETT为6.5±4.4（平均值±标准误，P<0.05）。输送效率还受MDI在气流通过ETT之前还是之后启动的影响，在气流中启动明显更有效。作者得出结论，MDI可将一定剂量的药物输送至气管，但输送效率低于自发呼吸患者中MDI给药的报告效率。
