靶向心脏代谢疾病中的阿片肽系统。
Targeting Apelinergic System in Cardiometabolic Disease.
机构信息
Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, School of Pharmacy, College of Health Sciences, Laramie, WY 82071, United States.
出版信息
Curr Drug Targets. 2017;18(15):1785-1791. doi: 10.2174/1389450117666160613105152.
BACKGROUND
Global burden of cardiometabolic disease warrants development of newer treatment strategies. Apelin is ubiquitously expressed endogenous peptide which is a ligand for the apelinergic (APJ) receptor. Apelin/APJ receptors regulate a variety of biological functions and have been implicated in cardiovascular and metabolic homeostasis. Consequently, the apelinergic pathway represents an attractive target to treat conditions associated with cardiometabolic syndrome.
OBJECTIVE
This review highlights the important regulatory role played by apelin in energy metabolism and cardiovascular function, and potential avenues that could be harnessed for therapeutic benefit.
CONCLUSION
Apelin/APJ system is a druggable target to treat or prevent a variety of cardiometabolic diseases.
背景
心血管代谢疾病的全球负担需要开发新的治疗策略。Apelin 是一种广泛表达的内源性肽，是 Apelinergic（APJ）受体的配体。Apelin/APJ 受体调节多种生物功能，并与心血管和代谢稳态有关。因此，阿皮林能途径代表了治疗与代谢综合征相关疾病的有吸引力的靶点。
目的
本综述强调了 Apelin 在能量代谢和心血管功能中的重要调节作用，以及可能用于治疗获益的潜在途径。
结论
Apelin/APJ 系统是治疗或预防多种心血管代谢疾病的可用药靶标。
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