中国红豆杉（南方红豆杉）中13种紫杉烷二萜类化合物对人宫颈癌HeLa细胞增殖的抑制作用

Inhibitory effect of 13 taxane diterpenoids from Chinese yew (Taxus chinensis var. mairei) on the proliferation of HeLa cervical cancer cells.

作者信息

Liu Hai-Sheng, Gao Yu-Huan, Liu Li-Hong, Liu Wei, Shi Qing-Wen, Dong Mei, Suzuki Toshikazu, Kiyota Hiromasa

机构信息

a Department of Hematology , Fourth Hospital of Hebei Medical University , Shijiazhuang , China.

b Department of Medical Oncology , Fourth Hospital of Hebei Medical University , Shijiazhuang , China.

出版信息

Biosci Biotechnol Biochem. 2016 Oct;80(10):1883-6. doi: 10.1080/09168451.2016.1194182. Epub 2016 Jun 9.

DOI:10.1080/09168451.2016.1194182

PMID:27296359

Abstract

The inhibitory effect of 13 taxanes isolated from the Chinese yew (Taxus chinensis var. mairei) on the proliferation of human cervical cancer HeLa cells were examined using an MTT assay. Four compounds having a hydrophobic cinnamate side chain showed antiproliferative activity, which may be due to increased cell permeability.

摘要

采用MTT法检测了从中国红豆杉（南方红豆杉）中分离出的13种紫杉烷对人宫颈癌HeLa细胞增殖的抑制作用。四种具有疏水肉桂酸酯侧链的化合物表现出抗增殖活性，这可能是由于细胞通透性增加所致。