Kalinowska Magdalena, Francesconi Anna
Dominick P. Purpura Department of Neuroscience, Rose F. Kennedy Center, Room 706, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
Curr Neuropharmacol. 2016;14(5):494-503. doi: 10.2174/1570159x13666150515234434.
Group I metabotropic glutamate receptors mediate slow excitatory neurotransmission in the central nervous system and are critical to activity-dependent synaptic plasticity, a cellular substrate of learning and memory. Dysregulated receptor signaling is implicated in neuropsychiatric conditions ranging from neurodevelopmental to neurodegenerative disorders. Importantly, group I metabotropic glutamate receptor signaling functions can be modulated by interacting proteins that mediate receptor trafficking, expression and coupling efficiency to signaling effectors. These interactions afford cell- or pathway-specific modulation to fine-tune receptor function, thus representing a potential target for pharmacological interventions in pathological conditions.
I 型代谢型谷氨酸受体介导中枢神经系统中的缓慢兴奋性神经传递，对依赖活动的突触可塑性至关重要，而突触可塑性是学习和记忆的细胞基础。受体信号失调与从神经发育障碍到神经退行性疾病等一系列神经精神疾病有关。重要的是，I 型代谢型谷氨酸受体信号功能可由介导受体运输、表达以及与信号效应器偶联效率的相互作用蛋白进行调节。这些相互作用实现了细胞或通路特异性调节，以微调受体功能，因此代表了病理状态下药理学干预的潜在靶点。
