通过手性固定相实现糖基亚砜的简便非对映体分离
Facile Diastereoseparation of Glycosyl Sulfoxides by Chiral Stationary Phase.
作者信息
Taniguchi Tohru, Asahata Mai, Nasu Akihito, Shichibu Yukatsu, Konishi Katsuaki, Monde Kenji
机构信息
Faculty of Advanced Life Science, Frontier Research Center for Post-Genome Science and Technology, Hokkaido University, Sapporo, Japan.
Faculty of Environmental Earth Science, Hokkaido University, Sapporo, Japan.
出版信息
Chirality. 2016 Jul;28(7):534-9. doi: 10.1002/chir.22610. Epub 2016 Jun 14.
Separation of the diastereomers of glycosyl sulfoxides differing in the sulfur chirality has been difficult. This article presents a fast and scalable method for their diastereoseparation using a chiral stationary phase. The usefulness of this method was demonstrated in a 500-mg scale separation within 20 min, and in the separation of trisaccharyl sulfoxide diastereomers. Chirality 28:534-539, 2016. © 2016 Wiley Periodicals, Inc.
分离硫手性不同的糖基亚砜非对映异构体一直很困难。本文提出了一种使用手性固定相快速且可扩展的非对映体分离方法。该方法的实用性在20分钟内500毫克规模的分离以及三糖基亚砜非对映异构体的分离中得到了证明。《手性》2016年第28卷，第534 - 539页。© 2016威利期刊公司。
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