二苄基丁内酯木脂素——结构多样性、生物合成、存在情况、鉴定及重要性综述

Dibenzylbutyrolactone Lignans - A Review of Their Structural Diversity, Biosynthesis, Occurrence, Identification and Importance.

作者信息

Solyomváry Anna, Beni Szabolcs, Boldizsar Imre

机构信息

Department of Pharmacognosy, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary.

Department of Plant Anatomy, Eötvös Loránd University, Budapest, Hungary.

出版信息

Mini Rev Med Chem. 2017;17(12):1053-1074. doi: 10.2174/1389557516666160614005828.

DOI:10.2174/1389557516666160614005828

PMID:27297675

Abstract

OBJECTIVE

Dibenzylbutyrolactone lignans represent a unique group of plant secondary metabolites with increasing significance in medicine. This review summarizes their structural characteristics and classification, as well as the biosynthesis starting in the chloroplast, and their supposed biological activity associated with plant defense mechanisms are also discussed. Over 85 natural dibenzylbutyrolactone lignans known to date and their corresponding plant sources are summarized herein for the first time, highlighting a taxon- and organ-specific accumulation of these compounds.

CONCLUSION

The isolation strategies, applied analytical methods and pharmacological activities of dibenzylbutyrolactone lignans are also thoroughly reviewed.

摘要

目的

二苄基丁内酯木脂素是一类独特的植物次生代谢产物，在医学上的重要性日益增加。本综述总结了它们的结构特征和分类，以及始于叶绿体的生物合成过程，并讨论了它们与植物防御机制相关的假定生物活性。本文首次总结了迄今为止已知的85种以上天然二苄基丁内酯木脂素及其相应的植物来源，突出了这些化合物在分类群和器官中的特异性积累。