Xu Wen-Hui, Zhao Ping, Wang Meng, Liang Qian
a Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China, Ministry of Education , Southwest Forestry University , Kunming , PR China.
Nat Prod Res. 2019 May;33(9):1357-1373. doi: 10.1080/14786419.2018.1474467. Epub 2018 May 16.
Furofuran lignans containing the 2,6-diaryl-3,7-dioxabicyclo[3.3.0]octane skeleton, represent one of the major subclasses of the lignan family of natural products. Furofuran lignans feature a wide variety of structures due to different substituents at aryl groups and diverse configurations at furofuran ring. Moreover, they exhibit a wide range of significant biological activities, including antioxidant, anti-inflammatory, cytotoxic, and antimicrobial activities. This review summarizes source, phytochemistry, and biological activities of 137 natural furofuran lignans isolated from 53 species in 41 genera of 27 plant families for the last 20 years, which provides a comprehensive information for further research of these furofuran lignans as potential pharmaceutical agents.
含有2,6 - 二芳基 - 3,7 - 二氧杂双环[3.3.0]辛烷骨架的呋喃呋喃木脂素是天然产物木脂素家族的主要亚类之一。由于芳基上不同的取代基以及呋喃呋喃环上多样的构型，呋喃呋喃木脂素具有多种多样的结构。此外，它们还表现出广泛的显著生物活性，包括抗氧化、抗炎、细胞毒性和抗菌活性。本文综述了过去20年从27个植物科41属53种植物中分离得到的137种天然呋喃呋喃木脂素的来源、植物化学和生物活性，为进一步研究这些呋喃呋喃木脂素作为潜在药物提供了全面的信息。
