脂质体包裹的利福平对小鼠鸟分枝杆菌复合群感染的治疗效果。
Therapeutic efficacy of liposome-entrapped rifampin against Mycobacterium avium complex infection induced in mice.
作者信息
Saito H, Tomioka H
机构信息
Department of Microbiology and Immunology, Shimane Medical University, Izumo, Japan.
出版信息
Antimicrob Agents Chemother. 1989 Apr;33(4):429-33. doi: 10.1128/AAC.33.4.429.
Abstract
Liposome-entrapped rifampin (RFP) was examined for therapeutic efficacy against experimental infection induced in mice by the Mycobacterium avium complex. Intraperitoneal injections (once daily, six times weekly) of liposome-entrapped RFP led to a greater reduction in bacterial growth in the lungs and spleen of infected mice than did free RFP alone. Liposome-entrapped RFP given to mice via the intramuscular or subcutaneous route failed to show such an increased therapeutic efficacy. RFP entrapped in the lipid layer of liposomal vesicles exhibited a level of therapeutic activity similar to that seen with RFP encapsulated in the inner solute of the vesicles. Entrapment of RFP in liposomal vesicles increased incorporation of the drug into host peritoneal macrophages and increased the activity of the agent against M. avium complex phagocytosed into the macrophages.
摘要
对脂质体包裹的利福平（RFP）治疗鸟分枝杆菌复合群引起的小鼠实验性感染的疗效进行了研究。腹腔注射（每日一次，每周六次）脂质体包裹的RFP比单独使用游离RFP能使感染小鼠肺部和脾脏中的细菌生长减少得更多。通过肌肉或皮下途径给小鼠注射脂质体包裹的RFP未能显示出这种增强的治疗效果。包裹在脂质体囊泡脂质层中的RFP表现出的治疗活性水平与包裹在囊泡内部溶质中的RFP相似。RFP包裹在脂质体囊泡中增加了药物在宿主腹腔巨噬细胞中的摄取，并增强了该制剂对巨噬细胞吞噬的鸟分枝杆菌复合群的活性。
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