口服含异烟肼、利福平及吡嗪酰胺的聚（丙交酯-乙交酯）微粒对实验性结核病的化疗潜力
Chemotherapeutic potential of orally administered poly(lactide-co-glycolide) microparticles containing isoniazid, rifampin, and pyrazinamide against experimental tuberculosis.
作者信息
Ul-Ain Qurrat, Sharma Sadhna, Khuller G K
机构信息
Department of Biochemistry, Postgraduate Institute of Medical Education & Research, Chandigarh 160 012, India.
出版信息
Antimicrob Agents Chemother. 2003 Sep;47(9):3005-7. doi: 10.1128/AAC.47.9.3005-3007.2003.
Abstract
Poly(lactide-co-glycolide) (PLG) microspheres (diameter, less than 3 microm) containing isoniazid, rifampin, and pyrazinamide were used in a sustained oral drug delivery system to treat murine tuberculosis. Drug levels above the MIC were observed up to 72 h in plasma and for 9 days in various organs. Relative bioavailability of encapsulated drugs was greater than that of free drugs. Chemotherapy results showed better or equivalent clearance of bacilli in the PLG-drug-administered group (weekly) than with free drugs (daily).
摘要
聚（丙交酯-乙交酯）（PLG）微球（直径小于3微米）含有异烟肼、利福平和吡嗪酰胺，被用于一种持续口服给药系统来治疗小鼠结核病。在血浆中观察到药物水平高于最低抑菌浓度（MIC）长达72小时，在各个器官中则持续9天。包封药物的相对生物利用度高于游离药物。化疗结果显示，PLG药物给药组（每周一次）对杆菌的清除效果优于或等同于游离药物给药组（每日一次）。
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