de Waard G A, Melenhorst M C A M, van Leeuwen M A H, Bogaard H J, Lely R J, van Royen N
VUmc, Amsterdam.
Ned Tijdschr Geneeskd. 2016;160:A9807.
Chronic thromboembolic pulmonary hypertension (CTEPH) is characterised by an elevated average blood pressure in the pulmonary artery (≥ 25 mmHg). This increase is secondary to fibrous organization of thromboembolic obstructions in the pulmonary arteries. CTEPH is associated with significant morbidity and mortality due to right-sided heart failure and ventilation-perfusion discrepancy. Therapy is aimed at normalising pulmonary artery pressure, and pulmonary endarterectomy is usually the treatment of first choice. When surgery is not possible because of peripheral disease localisation or comorbidity, percutaneous balloon pulmonary angioplasty (BPA) can be used. BPA is associated with improvements in functional status and haemodynamic profile. Initially procedural complications often occurred, but improvements in procedural technique have ensured that BPA is used increasingly worldwide. In this article, we discuss the history, procedural aspects and outcomes of BPA, and present our first experiences with BPA in a patient with CTEPH.
慢性血栓栓塞性肺动脉高压(CTEPH)的特征是肺动脉平均血压升高(≥25 mmHg)。这种升高继发于肺动脉血栓栓塞性梗阻的纤维组织形成。由于右心衰竭和通气-灌注差异,CTEPH与显著的发病率和死亡率相关。治疗旨在使肺动脉压力正常化,肺动脉内膜剥脱术通常是首选治疗方法。当由于外周病变定位或合并症而无法进行手术时,可以使用经皮球囊肺动脉血管成形术(BPA)。BPA与功能状态和血流动力学特征的改善相关。最初,手术并发症经常发生,但手术技术的改进确保了BPA在全球范围内的使用越来越多。在本文中,我们讨论了BPA的历史、手术方面和结果,并介绍了我们在一名CTEPH患者中使用BPA的首次经验。