Shenje Justin, Millard Peter S
Department of Epidemiology, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
Department of Epidemiology, Graduate Program in Public Health, University of New England, Portland, Maine, United States of America.
PLoS One. 2016 Jun 14;11(6):e0157065. doi: 10.1371/journal.pone.0157065. eCollection 2016.
The World Health Organization has solicited rapid and minimally invasive techniques to facilitate scale-up of voluntary medical male circumcision (VMMC).
Non-blinded randomized controlled field trial with 2:1 allocation ratio.
75 adult male volunteers.
Outpatient primary care clinic.
Open surgical circumcision under local anesthetic with suturing vs. Unicirc disposable instrument under topical anesthetic and wound sealing with cyanoacrylate tissue adhesive.
Intraoperative duration.
Intraoperative and postoperative pain; adverse events; time to healing; patient satisfaction; cosmetic result.
The intraoperative time was less with the Unicirc technique (median 12 vs. 25 min, p < 0.001). Wound healing and cosmetic results were superior in the Unicirc group. Adverse events were similar in both groups.
VMMC with Unicirc under topical anesthetic and wound sealing with cyanoacrylate tissue adhesive is rapid, heals by primary intention with superior cosmetic results, and is potentially safer and more cost-effective than open surgical VMMC.
Clinicaltrials.gov NCT02443792.
世界卫生组织已寻求快速且微创的技术，以促进扩大自愿男性包皮环切术（VMMC）的规模。
非盲法随机对照现场试验，分配比例为2:1。
75名成年男性志愿者。
门诊基层医疗诊所。
局部麻醉下开放手术包皮环切术并缝合与使用Unicirc一次性器械在表面麻醉下进行手术并用氰基丙烯酸酯组织粘合剂封闭伤口。
手术时长。
术中及术后疼痛；不良事件；愈合时间；患者满意度；美观效果。
使用Unicirc技术的手术时间更短（中位数分别为12分钟和25分钟，p<0.001）。Unicirc组的伤口愈合和美观效果更佳。两组的不良事件相似。
在表面麻醉下使用Unicirc进行VMMC并用氰基丙烯酸酯组织粘合剂封闭伤口，手术快速，一期愈合且美观效果更佳，与开放手术VMMC相比可能更安全且更具成本效益。
Clinicaltrials.gov NCT02443792。
