Torres Suárez E, Pinheiro R, Schrage N
Augenklinik, Krankenhaus Merheim, Kliniken der Stadt Köln, Ostmerheimer Str. 200, 51109, Köln, Deutschland.
Ophthalmologe. 2017 Feb;114(2):155-158. doi: 10.1007/s00347-016-0292-y.
Interferon α‑2b (IFN α‑2b) is an established and well-tolerated treatment for ocular surface squamous neoplasia (OSSN).
Report of complications in two patients with OSSN and rheumatoid arthritis treated with adjuvant topical IFN α‑2b.
One patient developed a scleral melt and the other one severe keratitis. After discontinuing treatment with IFN α‑2b both patients showed considerable improvement.
Immunosuppressed patients with OSSN under topical IFN α‑2b should be closely monitored for early detection of complications.
干扰素α-2b（IFNα-2b）是一种已确立且耐受性良好的治疗眼表鳞状上皮肿瘤（OSSN）的方法。
报告两例接受辅助性局部应用IFNα-2b治疗的OSSN合并类风湿性关节炎患者的并发症情况。
一名患者发生巩膜溶解，另一名患者发生严重角膜炎。停用IFNα-2b治疗后，两名患者均有明显改善。
局部应用IFNα-2b治疗的OSSN免疫抑制患者应密切监测，以便早期发现并发症。
