真菌性角膜炎背景下的眼表鳞状上皮肿瘤：一种罕见的共发病情况。
Ocular surface squamous neoplasia in a setting of fungal keratitis: a rare co-occurrence.
作者信息
Singh Swati, Mittal Ruchi, Narang Purvasha, Mittal Vikas
机构信息
Ophthalmic Plastics, Orbit and Ocular Oncology Services, L J Eye Institute, Ambala, India.
Dalmia Ophthalmic Pathology Service, L V Prasad Eye Institute, Mithu Tulsi Chanrai Campus, Bhubaneswar, India.
出版信息
Int Ophthalmol. 2019 Mar;39(3):717-720. doi: 10.1007/s10792-018-0864-8. Epub 2018 Feb 8.
PURPOSE
To describe a rare co-occurrence of ocular surface squamous neoplasia (OSSN) in a patient with microbial keratitis.
METHODS
Case report.
RESULTS
We describe a 68-years female who developed ocular surface squamous neoplasia (OSSN) in an eye with culture proven severe fungal keratitis of 5 months duration, which progressed to endophthalmitis. She was managed with extended enucleation for left eye. Histopathology examination was consistent with squamous cell carcinoma of ocular surface with no corneal stromal/scleral/anterior chamber involvement. She received adjuvant chemotherapy with topical Interferon alpha2b (3 cycles) for positive margins. Six months after treatment, she is completely tumor free.
CONCLUSION
Co-occurrence of OSSN and chronic fungal keratitis is rare. We recommend that patients with chronic ocular infections should be examined and followed closely for abnormally thickened limbal areas.
目的
描述1例微生物性角膜炎患者罕见地同时发生眼表鳞状上皮肿瘤（OSSN）。
方法
病例报告。
结果
我们报告1例68岁女性，其患严重真菌性角膜炎5个月，经培养证实，在患眼发生眼表鳞状上皮肿瘤，病情进展为眼内炎。对其左眼实施了扩大眼球摘除术。组织病理学检查结果符合眼表鳞状细胞癌，角膜基质/巩膜/前房未受累。因其手术切缘阳性，接受了局部干扰素α2b辅助化疗（3个周期）。治疗6个月后，她体内已无肿瘤。
结论
OSSN与慢性真菌性角膜炎同时发生的情况罕见。我们建议，应对慢性眼部感染患者进行检查，并密切随访其角膜缘区域是否异常增厚。
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