Falanga V, Soter N A, Kerdel F A
Department of Dermatology and Cutaneous Surgery, University of Miami (Fla) School of Medicine.
Arch Dermatol. 1989 Jun;125(6):805-8.
In a patient with eosinophilic fasciitis, a biopsy specimen obtained within 4 weeks of the onset of symptoms showed infiltration of the subcutis and fascia with mast cells, and there was up to a 19-fold increase in plasma histamine levels. The patient improved and experienced softening of the skin when treated with systemic corticosteroids and a histamine2-receptor antagonist, and her plasma histamine level returned to normal. Tissue mast cell infiltration and excessive plasma histamine levels were not present in two otherwise similar patients with eosinophilic fasciitis who were studied 7 months after disease onset. It is possible that mast cells play a pathogenic role in some patients with eosinophilic fasciitis.
在一名嗜酸性筋膜炎患者中，症状出现4周内获取的活检标本显示皮下组织和筋膜有肥大细胞浸润，血浆组胺水平最高升高了19倍。该患者接受全身用皮质类固醇和组胺2受体拮抗剂治疗后病情改善，皮肤变软，其血浆组胺水平恢复正常。在另外两名病情相似的嗜酸性筋膜炎患者中，在疾病发作7个月后进行研究时未发现组织肥大细胞浸润和血浆组胺水平过高的情况。肥大细胞可能在一些嗜酸性筋膜炎患者中起致病作用。
