Boltze Johannes, Wagner Daniel-Christoph, Barthel Henryk, Gounis Matthew J
Fraunhofer Research Institution for Marine Biotechnology and Institute for Medical and Marine Biotechnology, University of Lübeck, Mönkhofer Weg 239a, 23562, Lübeck, Germany.
Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany.
Transl Stroke Res. 2016 Aug;7(4):343-53. doi: 10.1007/s12975-016-0475-5. Epub 2016 Jun 14.
Academic-industry collaborations are an emerging format of translational stroke research. Next to classic contract research models, a multitude of collaboration models has been developed, some of which even allowing for multinational or intercontinental research programs. This development has recently been paralleled by first successful attempts to overcome the translational stroke research road block, such as the unprecedented success of novel endovascular approaches or the advent of the multicenter preclinical trial concept. While the first underlines the role of the industry as a major innovation driver in stroke research, the latter will require enrollment of industrial partners for optimal output. Moreover, academic-industry partnerships are invaluable to bridge the translational "valley of death" as well as funding gaps in times of dwindling public funding and declining high risk capital investments. However, these collaborations are also subject to relevant challenges because interests, values, and aims often significantly differ between cademia and industry. Here, we describe common academic-industry collaboration models as well as associated benefits and challenges in the stroke research arena. We also suggest strategies for improved planning, implementation, guidance, and utilization of academic-industry collaborations to the maximum mutual benefit.
学术-产业合作是转化性中风研究中一种新兴的形式。除了传统的合同研究模式外，还开发了多种合作模式，其中一些甚至允许开展跨国或跨洲的研究项目。最近，这种发展与首次成功尝试克服转化性中风研究的障碍并行，比如新型血管内治疗方法取得了前所未有的成功，或者多中心临床前试验概念的出现。前者凸显了产业界作为中风研究主要创新驱动力的作用，而后者将需要产业合作伙伴的参与以实现最佳产出。此外，在公共资金减少和高风险资本投资下降的时期，学术-产业伙伴关系对于弥合转化性“死亡谷”以及资金缺口具有不可估量的价值。然而，这些合作也面临相关挑战，因为学术界和产业界的利益、价值观和目标往往存在显著差异。在此，我们描述了中风研究领域常见的学术-产业合作模式以及相关的益处和挑战。我们还提出了一些策略，以改进学术-产业合作的规划、实施、指导和利用，实现最大程度的互利共赢。
