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肺癌转移至脊柱

LUNG CANCER METASTASIS TO THE SPINE.

作者信息

Aydin Ahmet Levent, Emel Erhan, Sasani Mehdi, Gomleksiz Cengiz, Oktenoglu Tunc, Ozer Ali Fahir

机构信息

Koc University School of Medicine.

出版信息

Turk Neurosurg. 2016;26(4):635-642. doi: 10.5137/1019-5149.JTN.8476-13.0. Epub 2013 Jul 8.

Abstract

BACKGROUND

In patients affected by malignant tumors, spinal column metastases are frequent. Incidence varies between 30% -70%. Lung cancer is the second most frequent cancer invading spine in women, following breast cancer. In men, the first. All patients are under risk of symptomatic spinal cord compression. Prognosis is poor. Indications for surgery are progressive neurologic deficit, intractable pain, and impending vertebral fracture. Treatment is to preserve neurologic function, promote pain relief and provide functional improvement.

STUDY DESIGN

Report of five patients with symptomatic thoracic vertebral invasion secondary to lung cancer who underwent nine surgical procedures. In all patients, invasion to spinal column was from neighbouring lung tissue by direct extension or through segmental arteries.

METHODS

Five patients with symptomatic metastatic spinal cord compression at thoracal level, secondary to lung cancer were operated. They were evaluated regarding neurologic status, pain and disability scores, tumor type, level, surgical procedure.

CONCLUSION

Lung cancer is an aggressive tumor. Patients with symptomatic spinal cord compression must be treated aggressively. With current spinal surgical techniques and with the coordinated effort, the life expectancy and quality of these patients are extended.

摘要

背景

在恶性肿瘤患者中,脊柱转移很常见。发病率在30%至70%之间。肺癌是女性中第二常见的侵犯脊柱的癌症,仅次于乳腺癌。在男性中,肺癌是最常见的。所有患者都有发生症状性脊髓压迫的风险。预后较差。手术指征为进行性神经功能缺损、顽固性疼痛和即将发生的椎体骨折。治疗目的是保留神经功能、促进疼痛缓解并改善功能。

研究设计

报告5例因肺癌导致有症状的胸椎侵犯并接受了9次手术的患者。在所有患者中,脊柱侵犯均由邻近肺组织直接蔓延或通过节段动脉所致。

方法

对5例因肺癌导致有症状的胸段转移性脊髓压迫患者进行了手术。对他们的神经状态、疼痛和残疾评分、肿瘤类型、部位及手术方式进行了评估。

结论

肺癌是一种侵袭性肿瘤。有症状性脊髓压迫的患者必须积极治疗。借助当前的脊柱外科技术和协同努力,这些患者的预期寿命和生活质量得以延长。

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