Wewel Joshua T, O'Toole John E
Atlanta Brain and Spine Care, Piedmont Healthcare, Atlanta, Georgia.
Department of Neurosurgery, University Medical Center, Chicago, Illinois, US.
Neurooncol Pract. 2020 Nov 18;7(Suppl 1):i5-i9. doi: 10.1093/nop/npaa046. eCollection 2020 Nov.
The spine is a frequent location for metastatic disease. As local control of primary tumor pathology continues to improve, survival rates improve and, by extension, the opportunity for metastasis increases. Breast, lung, and prostate cancer are the leading contributors to spinal metastases. Spinal metastases can manifest as bone pain, pathologic fractures, spinal instability, nerve root compression, and, in its most severe form, spinal cord compression. The global extent of disease, the spinal burden, neurologic status, and life expectancy help to categorize patients as to their candidacy for treatment options. Efficient identification and workup of those with spinal metastases will expedite the treatment cascade and improve quality of life.
脊柱是转移性疾病的常见部位。随着原发性肿瘤病理学的局部控制不断改善，生存率提高，进而转移的机会增加。乳腺癌、肺癌和前列腺癌是脊柱转移的主要原因。脊柱转移可表现为骨痛、病理性骨折、脊柱不稳定、神经根受压，最严重的形式是脊髓受压。疾病的整体范围、脊柱负担、神经状态和预期寿命有助于将患者分类，以确定其是否适合治疗方案。对脊柱转移患者进行有效的识别和检查将加快治疗进程并提高生活质量。
