替代健康饮食指数与中国成年人群致命和非致命急性心肌梗死风险较低相关。
The Alternative Healthy Eating Index Is Associated with a Lower Risk of Fatal and Nonfatal Acute Myocardial Infarction in a Chinese Adult Population.
作者信息
Neelakantan Nithya, Naidoo Nasheen, Koh Woon-Puay, Yuan Jian-Min, van Dam Rob M
机构信息
Saw Swee Hock School of Public Health and.
Department of Pathology, Stellenbosch University, Cape Town, South Africa;
出版信息
J Nutr. 2016 Jul;146(7):1379-86. doi: 10.3945/jn.116.231605. Epub 2016 Jun 15.
BACKGROUND
Indexes to quantify adherence to recommended dietary patterns have been developed for Western populations, but it is unclear whether these indexes can predict acute myocardial infarction (AMI) in Asian populations.
OBJECTIVES
We aimed to investigate the association between the Alternative Healthy Eating Index (AHEI)-2010 and risk of AMI and to evaluate potential mediation by traditional cardiovascular risk factors in a Chinese population.
METHODS
A nested case-control study in 751 incident cases of AMI (564 nonfatal and 288 fatal) and 1443 matched controls was conducted within the prospective Singapore Chinese Health Study, a cohort of ethnic Chinese men and women aged 45-75 y. At baseline, habitual diet was assessed by using a validated, semiquantitative food-frequency questionnaire. AMI cases were ascertained via linkage with nationwide hospital databases (confirmed through medical record review) and the Singapore Birth and Death Registry. We evaluated the association between the AHEI-2010 and cardiovascular risk factors, including glycated hemoglobin, high-sensitivity C-reactive protein, creatinine, plasma lipids (LDL and HDL cholesterol, triglycerides), and blood pressure. ORs and 95% CIs were computed by using multivariable-adjusted conditional logistic regression models.
RESULTS
Higher AHEI-2010 scores were associated with a lower risk of AMI (OR for the highest quartile compared with the lowest quartile: 0.62; 95% CI: 0.47, 0.81; P-trend < 0.001), with similar associations for fatal (OR: 0.60; 95% CI: 0.39, 0.94; P-trend = 0.009) and nonfatal (OR: 0.59; 95% CI: 0.43, 0.81; P-trend = 0.002) AMI. This association was only slightly attenuated after adjustment for potential biological intermediates (OR: 0.64; 95% CI: 0.48, 0.86; P-trend = 0.003).
CONCLUSIONS
Adherence to dietary recommendations as reflected in the AHEI-2010 was associated with a substantially lower risk of fatal and nonfatal AMI in an Asian population, and this association was largely independent of traditional cardiovascular risk factors.
背景
已针对西方人群开发了用于量化对推荐饮食模式依从性的指标，但尚不清楚这些指标能否预测亚洲人群的急性心肌梗死（AMI）。
目的
我们旨在研究2010年替代健康饮食指数（AHEI）与AMI风险之间的关联，并评估中国人群中传统心血管危险因素的潜在中介作用。
方法
在新加坡华人健康研究（一项针对45 - 75岁华裔男性和女性的队列研究）中进行了一项巢式病例对照研究，纳入751例AMI新发病例（564例非致命性和288例致命性）以及1443例匹配对照。在基线时，使用经过验证的半定量食物频率问卷评估习惯性饮食。通过与全国医院数据库（经病历审查确认）以及新加坡出生和死亡登记处的数据链接确定AMI病例。我们评估了AHEI - 2010与心血管危险因素之间的关联，这些危险因素包括糖化血红蛋白、高敏C反应蛋白、肌酐、血脂（低密度脂蛋白和高密度脂蛋白胆固醇、甘油三酯）以及血压。使用多变量调整的条件逻辑回归模型计算比值比（OR）和95%置信区间（CI）。
结果
较高的AHEI - 2010得分与较低的AMI风险相关（最高四分位数与最低四分位数相比的OR：0.62；95%CI：0.47，0.81；P趋势<0.001），致命性（OR：0.60；95%CI：0.39，0.94；P趋势 = 0.009）和非致命性（OR：0.59；95%CI：0.43，0.81；P趋势 = 0.002）AMI的关联相似。在对潜在生物学中介因素进行调整后，这种关联仅略有减弱（OR：0.64；95%CI：0.48，0.86；P趋势 = 0.003）。
结论
AHEI - 2010所反映的对饮食建议的依从性与亚洲人群中致命性和非致命性AMI的风险显著降低相关，并且这种关联在很大程度上独立于传统心血管危险因素。
Zotero 插件