Mathews Marc J, Liebenberg Leon, Mathews Edward H
CRCED, North-West University, and Consultants to TEMM International (Pty) Ltd, P.O. Box 11207, Silver Lakes, 0054, South Africa.
Nutr J. 2015 Apr 2;14:33. doi: 10.1186/s12937-015-0011-6.
Moderate alcohol consumption is associated with a lower risk for coronary heart disease (CHD). A suitably integrated view of the CHD pathogenesis pathway will help to elucidate how moderate alcohol consumption could reduce CHD risk.
A comprehensive literature review was conducted focusing on the pathogenesis of CHD. Biomarker data were further systematically analysed from 294 cohort studies, comprising 1 161 560 subjects. From the above a suitably integrated CHD pathogenetic system for the purpose of this study was developed.
The resulting integrated system now provides insight into the integrated higher-order interactions underlying CHD and moderate alcohol consumption. A novel 'connection graph' further simplifies these interactions by illustrating the relationship between moderate alcohol consumption and the relative risks (RR) attributed to various measureable CHD serological biomarkers. Thus, the possible reasons for the reduced RR for CHD with moderate alcohol consumption become clear at a glance.
An integrated high-level model of CHD, its pathogenesis, biomarkers, and moderate alcohol consumption provides a summary of the evidence that a causal relationship between CHD risk and moderate alcohol consumption may exist. It also shows the importance of each CHD pathway that moderate alcohol consumption influences.
适度饮酒与较低的冠心病（CHD）风险相关。对冠心病发病机制途径进行适当的综合分析，将有助于阐明适度饮酒如何降低冠心病风险。
针对冠心病发病机制进行了全面的文献综述。对来自294项队列研究（包括1161560名受试者）的生物标志物数据进行了进一步的系统分析。据此，为本研究构建了一个适当的综合冠心病发病系统。
所得的综合系统现在能够洞察冠心病和适度饮酒背后的综合高阶相互作用。一种新颖的“连接图”通过展示适度饮酒与各种可测量的冠心病血清生物标志物的相对风险（RR）之间的关系，进一步简化了这些相互作用。因此，适度饮酒导致冠心病RR降低的可能原因一目了然。
一个关于冠心病及其发病机制、生物标志物和适度饮酒的综合高级模型，总结了冠心病风险与适度饮酒之间可能存在因果关系的证据。它还显示了适度饮酒所影响的每条冠心病途径的重要性。
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