Hogan David B, Fiest Kirsten M, Roberts Jodie I, Maxwell Colleen J, Dykeman Jonathan, Pringsheim Tamara, Steeves Thomas, Smith Eric E, Pearson Dawn, Jetté Nathalie
1Brenda Strafford Chair in Geriatric Medicine,University of Calgary,Calgary,Alberta,Canada.
2Hotchkiss Brain Institute,University of Calgary,Calgary,Alberta,Canada.
Can J Neurol Sci. 2016 Apr;43 Suppl 1:S83-95. doi: 10.1017/cjn.2016.2.
Population-based prevalence and incidence studies are essential for understanding the societal burden of dementia with Lewy bodies (DLB).
The MEDLINE and EMBASE databases were searched to identify publications addressing the incidence and/or prevalence of DLB. References of included articles and prior systematic reviews were searched for additional studies. Two reviewers screened all abstracts and full-text reviews, abstracted data and performed quality assessments.
Twenty-two studies were included. Incidence rates ranged from 0.5 to 1.6 per 1000 person-years. DLB accounted for 3.2-7.1% of all dementia cases in the incidence studies. Point and period prevalence estimates ranged from 0.02 to 63.5 per 1000 persons. Increasing prevalence estimates were reported with increasing age. DLB accounted for from 0.3 to 24.4% of all cases of dementia in the prevalence studies.
DLB becomes more common with increasing age and accounts for about 5% of all dementia cases in older populations.
基于人群的患病率和发病率研究对于理解路易体痴呆（DLB）的社会负担至关重要。
检索MEDLINE和EMBASE数据库，以识别涉及DLB发病率和/或患病率的出版物。检索纳入文章的参考文献和先前的系统评价，以寻找其他研究。两名审阅者筛选所有摘要和全文综述，提取数据并进行质量评估。
纳入22项研究。发病率范围为每1000人年0.5至1.6例。在发病率研究中，DLB占所有痴呆病例的3.2 - 7.1%。时点患病率和期间患病率估计范围为每1000人0.02至63.5例。随着年龄增长，患病率估计值增加。在患病率研究中，DLB占所有痴呆病例的0.3至24.4%。
DLB随着年龄增长变得更加常见，在老年人群中约占所有痴呆病例的5%。
