Hogan David B, Jetté Nathalie, Fiest Kirsten M, Roberts Jodie I, Pearson Dawn, Smith Eric E, Roach Pamela, Kirk Andrew, Pringsheim Tamara, Maxwell Colleen J
1Brenda Strafford Chair in Geriatric Medicine,University of Calgary,Calgary,Alberta,Canada.
2Hotchkiss Brain Institute,University of Calgary,Calgary,Alberta,Canada.
Can J Neurol Sci. 2016 Apr;43 Suppl 1:S96-S109. doi: 10.1017/cjn.2016.25.
Population-based prevalence and incidence studies are essential for understanding the burden of frontotemporal dementia (FTD).
The MEDLINE and EMBASE databases were searched to identify population-based publications from 1985 to 2012, addressing the incidence and/or prevalence of FTD. References of included articles and prior systematic reviews were searched for additional studies. Two reviewers screened all abstracts and full-text reviews, abstracted data and performed quality assessments.
Twenty-six studies were included. Methodological limitations led to wide ranges in the estimates for prevalence (point prevalence 0.01-4.6 per 1000 persons; period prevalence 0.16-31.04 per 1000 persons) and incidence (0.0-0.3 per 1000 person-years). FTD accounted for an average of 2.7% (range 0-9.1%) of all dementia cases among prevalence studies that included subjects 65 and older compared to 10.2% (range 2.8-15.7%) in studies restricted to those aged less than 65. The cumulative numbers of male (373 [52.5%]) and female (338 [47.5%]) cases from studies reporting this information were nearly equal (p=0.18). The behavioural variant FTD (bvFTD) was almost four times as common as the primary progressive aphasias.
Population-based estimates for the epidemiology of FTD varied widely in the included studies. Refinements in the diagnostic process, possibly by the use of validated biomarkers or limiting case ascertainment to specialty services, are needed to obtain more precise estimates of the prevalence and incidence of FTD.
基于人群的患病率和发病率研究对于了解额颞叶痴呆（FTD）的负担至关重要。
检索MEDLINE和EMBASE数据库，以识别1985年至2012年期间基于人群的关于FTD发病率和/或患病率的出版物。检索纳入文章的参考文献和先前的系统评价以获取更多研究。两名评审员筛选所有摘要和全文综述，提取数据并进行质量评估。
纳入26项研究。方法学上的局限性导致患病率估计值（时点患病率为每1000人0.01 - 4.6例；期间患病率为每1000人0.16 - 31.04例）和发病率（每1000人年0.0 - 0.3例）的范围较宽。在纳入65岁及以上受试者的患病率研究中，FTD占所有痴呆病例的平均比例为2.7%（范围为0 - 9.1%），而在仅限于65岁以下人群的研究中这一比例为10.2%（范围为2.8 - 15.7%）。报告了该信息的研究中，男性（373例[52.5%]）和女性（338例[47.5%]）病例的累计数量几乎相等（p = 0.18）。行为变异型FTD（bvFTD）的常见程度几乎是原发性进行性失语症的四倍。
纳入研究中基于人群的FTD流行病学估计值差异很大。需要改进诊断过程，可能通过使用经过验证的生物标志物或限制病例确诊于专科服务，以获得FTD患病率和发病率更精确的估计值。
