Mitropoulos K A, Miller G J, Reeves B E, Wilkes H C, Cruickshank J K
MRC Epidemiology and Medical Care Unit, Northwick Park Hospital, Harrow, Middlesex, U.K.
Atherosclerosis. 1989 Apr;76(2-3):203-8. doi: 10.1016/0021-9150(89)90104-4.
A community survey of factor VII coagulant activity (VIIc) and the lipoprotein profile in non-fasting plasma of middle-aged men in NW London was undertaken to search for the determinants of VIIc in the general community. The data demonstrates that associations between VIIc and the plasma concentrations of cholesterol and of triglycerides previously shown in the general population can be explained by the strong and positive associations between VIIc and the large lipoprotein particles, chylomicrons, VLDL and IDL. Consistent with the possibility that the concentration of large lipoproteins determines the in vivo reactivity of factor VII, the association between VIIc and the ratio of lipid in the d greater than 1.019 fraction to the total plasma lipid was also highly significant but negative. The observed correlations between VIIc and lipoproteins smaller than VLDL may be the product of the interrelations that exist between the lipoprotein fractions in plasma. However, the associations between VIIc and the chylomicron lipid concentrations are especially strong when allowance is made for the considerable bias towards zero in the observed correlation, due to large within-person variance in chylomicron concentration.
对伦敦西北部中年男性非空腹血浆中的凝血因子 VII 凝血活性（VIIc）和脂蛋白谱进行了一项社区调查，以寻找普通社区中 VIIc 的决定因素。数据表明，先前在普通人群中显示的 VIIc 与血浆胆固醇和甘油三酯浓度之间的关联，可以通过 VIIc 与大脂蛋白颗粒、乳糜微粒、极低密度脂蛋白（VLDL）和中间密度脂蛋白（IDL）之间强烈的正相关来解释。与大脂蛋白浓度决定因子 VII 体内反应性的可能性一致，VIIc 与密度大于 1.019 部分的脂质与总血浆脂质的比率之间的关联也非常显著，但呈负相关。观察到的 VIIc 与小于 VLDL 的脂蛋白之间的相关性可能是血浆中脂蛋白组分之间存在的相互关系的产物。然而，当考虑到由于乳糜微粒浓度的个体内差异较大，观察到的相关性存在相当大的向零偏差时，VIIc 与乳糜微粒脂质浓度之间的关联尤其强烈。
