缓解期双相情感障碍和复发性抑郁症患者心率变异性降低。
Reduced heart rate variability in remitted bipolar disorder and recurrent depression.
作者信息
Bassett Darryl, Bear Natasha, Nutt David, Hood Sean, Bassett Sherylee, Hans Davinder
机构信息
University of Notre Dame, Fremantle, WA, Australia The University of Western Australia, Nedlands, WA, Australia Hollywood Specialist Centre, Nedlands, WA, Australia
Telethon Kids Institute, Subiaco, WA, Australia.
出版信息
Aust N Z J Psychiatry. 2016 Aug;50(8):793-804. doi: 10.1177/0004867416652734. Epub 2016 Jun 15.
OBJECTIVE
There is evidence that mood disorders are associated with impaired parasympathetic nervous system function and consequently increased morbidity and mortality. Our study addresses whether this impairment persists into remission in unipolar and bipolar disorders.
METHODS
Heart Rate Variability was measured in groups of subjects during remission, with Bipolar Affective Disorder I (n = 29), recurrent Major Depressive Disorder (n = 41) and a healthy control group (n = 38), during the bedtime period.
RESULTS
Heart Rate Variability was found to be lower in the bipolar and depression groups, compared with control subjects, using the Root Mean Square of Successive Distances variable, and lower in the depression group using the Standard Deviation of Normal to Normal variable and the Standard Deviation, Poincare Plot variable.
CONCLUSION
Autonomic function during bedtime was impaired in subjects with Bipolar I and recurrent Major Depressive Disorder, despite clinical remission. This has significant implications for the morbidity and mortality of patients with major mood disorders.
目的
有证据表明情绪障碍与副交感神经系统功能受损相关，进而导致发病率和死亡率增加。我们的研究探讨这种损害在单相和双相情感障碍缓解期是否持续存在。
方法
在缓解期对患有I型双相情感障碍（n = 29）、复发性重度抑郁症（n = 41）的受试者组以及健康对照组（n = 38）在就寝期间测量心率变异性。
结果
使用逐次距离均方根变量时，双相情感障碍组和抑郁症组的心率变异性低于对照组；使用正常到正常间期标准差变量和庞加莱图标准差变量时，抑郁症组的心率变异性低于对照组。
结论
尽管临床症状缓解，但I型双相情感障碍和复发性重度抑郁症患者在就寝期间的自主神经功能仍受损。这对重度情绪障碍患者的发病率和死亡率具有重要意义。
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