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白细胞介素-6在药物性牙龈增生患者中的免疫表达

Immunoexpression of interleukin-6 in drug-induced gingival overgrowth patients.

作者信息

Ganesh P R

机构信息

Department of Periodontics and Implantology, Government Dental College, Chennai, Tamil Nadu, India.

出版信息

Contemp Clin Dent. 2016 Apr-Jun;7(2):140-5. doi: 10.4103/0976-237X.183048.

DOI:10.4103/0976-237X.183048
PMID:27307657
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4906853/
Abstract

BACKGROUND

To analyze the role of proinflammatory cytokines in drug-induced gingival enlargement in Indian population.

AIM

To evaluate for the presence of interleukin-6 (IL-6) in drug-induced gingival enlargement and to compare it with healthy control in the absence of enlargement.

MATERIALS AND METHODS

Thirty-five patients selected for the study and divided into control group (10) and study group (25) consisting of phenytoin (10); cyclosporin (10) and nifedipine (5) induced gingival enlargement. Gingival overgrowth index of Seymour was used to assess overgrowth and allot groups. Under LA, incisional biopsy done, tissue sample fixed in 10% formalin and immunohistochemically evaluated for the presence of IL-6 using LAB-SA method, Labeled- Streptavidin-Biotin Method (LAB-SA kit from Zymed- 2(nd) generation LAB-SA detection system, Zymed Laboratories, CA). The results of immunohistochemistry were statistically analyzed using Kruskaal-Wallis and Mann-Whitney test.

RESULTS

The data obtained from immunohistochemistry assessment shows that drug-induced gingival overgrowth (DIGO) samples express more IL-6 than control group and cyclosporin expresses more IL-6 followed by phenytoin and nifedipine.

CONCLUSION

Increased IL-6 expression was noticed in all three DIGO groups in comparison with control group. Among the study group, cyclosporin expressed maximum IL-6 expression followed by phenytoin and nifedipine.

摘要

背景

分析促炎细胞因子在印度人群药物性牙龈增生中的作用。

目的

评估白细胞介素-6（IL-6）在药物性牙龈增生中的存在情况，并将其与无牙龈增生的健康对照组进行比较。

材料与方法

选取35例患者进行研究，分为对照组（10例）和研究组（25例），研究组包括苯妥英钠所致牙龈增生（10例）、环孢素所致牙龈增生（10例）和硝苯地平所致牙龈增生（5例）。采用西摩牙龈增生指数评估增生情况并分组。在局部麻醉下进行切口活检，将组织样本固定于10%福尔马林中，采用LAB-SA法（来自Zymed的第二代LAB-SA检测系统，Zymed Laboratories，加利福尼亚州）免疫组织化学评估IL-6的存在情况。免疫组织化学结果采用Kruskaal-Wallis和Mann-Whitney检验进行统计学分析。

结果

免疫组织化学评估获得的数据显示，药物性牙龈增生（DIGO）样本表达的IL-6比对照组多，环孢素表达的IL-6最多，其次是苯妥英钠和硝苯地平。

结论

与对照组相比，所有三个DIGO组均观察到IL-6表达增加。在研究组中，环孢素表达的IL-6最多，其次是苯妥英钠和硝苯地平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9bd/4906853/a32eef8b99df/CCD-7-140-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9bd/4906853/642671983245/CCD-7-140-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9bd/4906853/077750e4f3a0/CCD-7-140-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9bd/4906853/f5518cee2cfc/CCD-7-140-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9bd/4906853/f33013b9be68/CCD-7-140-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9bd/4906853/a32eef8b99df/CCD-7-140-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9bd/4906853/642671983245/CCD-7-140-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9bd/4906853/1a3a2c76a4f9/CCD-7-140-g006.jpg
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