健康个体、硝苯地平诱导的牙龈增生患者及硝苯地平无反应者牙龈组织中的血管紧张素II水平
Angiotensin II Levels in Gingival Tissues from Healthy Individuals, Patients with Nifedipine Induced Gingival Overgrowth and Non Responders on Nifedipine.
作者信息
Balaji Anitha, Balaji Thodur Madapusi, Rao Suresh Ranga
机构信息
Professor, Department of Periodontology, Shree Balaji Dental College and Hospital , Pallikaranai, Chennai, Tamil Nadu, India .
Associate Professor, Department of Periodontology, Faculty of Dental Sciences, Sri Ramachandra University , Porur, Chennai, Tamil Nadu, India .
出版信息
J Clin Diagn Res. 2015 Aug;9(8):ZC92-4. doi: 10.7860/JCDR/2015/14492.6388. Epub 2015 Aug 1.
CONTEXT
The Renin Angiotensin system has been implicated in the pathogenesis of Drug Induced Gingival Overgrowth (DIGO), a fibrotic condition, caused by Phenytoin, Nifedipine and Cyclosporine.
AIM
This study quantified Angiotensin II levels in gingival tissue samples obtained from healthy individuals, patients on Nifedipine manifesting/not manifesting drug induced gingival overgrowth.
MATERIALS AND METHODS
Gingival tissue samples were obtained from healthy individuals (n=24), patients on nifidipine manifesting gingival overgrowth (n= 18) and patients on nifidipine not manifesting gingival overgrowth (n=8). Angiotensin II levels were estimated in the samples using a commercially available ELISA kit.
RESULTS
Angiotensin II levels were significantly elevated in patients on Nifedipine manifesting gingival overgrowth compared to the other 2 groups (p<0.01).
CONCLUSION
The results of the study give an insight into the role played by Angiotensin II in the pathogenesis of drug induced gingival overgrowth.
背景
肾素血管紧张素系统与药物性牙龈增生（DIGO）的发病机制有关，DIGO是一种由苯妥英钠、硝苯地平和环孢素引起的纤维化病症。
目的
本研究对从健康个体、服用硝苯地平且出现/未出现药物性牙龈增生的患者获取的牙龈组织样本中的血管紧张素II水平进行了量化。
材料与方法
从健康个体（n = 24）、服用硝苯地平且出现牙龈增生的患者（n = 18）以及服用硝苯地平但未出现牙龈增生的患者（n = 8）获取牙龈组织样本。使用市售ELISA试剂盒对样本中的血管紧张素II水平进行评估。
结果
与其他两组相比，服用硝苯地平且出现牙龈增生的患者的血管紧张素II水平显著升高（p<0.01）。
结论
该研究结果深入揭示了血管紧张素II在药物性牙龈增生发病机制中所起的作用。
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