Frost F, Nanninga J, Penn R, Savoy S, Wu Y
Department of Physical Medicine and Rehabilitation, Case Western Reserve University, Cleveland Metropolitan General/Highland View Hospital, OH 44109.
Am J Phys Med Rehabil. 1989 Jun;68(3):112-5.
Intrathecal administration of Baclofen, a GABA agonist, through an implantable drug delivery pump has been demonstrated to be effective in the treatment of limb spasticity in patients with myelopathy. Three patients, followed before and after pump placement, experienced satisfactory spasticity relief and improvement in areas of self-care and mobility. Improvement in the bladder management programs of each patient was noted. These changes coincided with improvement on urodynamic studies, defined as either an increase in bladder capacity or a decrease in sphincter dyssynergia. Changes in bladder function were associated with the initiation of intrathecal therapy and with changes in pump-delivered dosages. In selected patients, intrathecal baclofen infusion can have a beneficial effect on bladder management programs.
通过植入式给药泵鞘内注射γ-氨基丁酸（GABA）激动剂巴氯芬已被证明可有效治疗脊髓病患者的肢体痉挛。三名患者在泵植入前后接受随访，痉挛得到了令人满意的缓解，自我护理和活动能力方面也有所改善。注意到每位患者膀胱管理方案都有改善。这些变化与尿动力学研究的改善相吻合，尿动力学改善定义为膀胱容量增加或括约肌协同失调减少。膀胱功能的变化与鞘内治疗的开始以及泵输送剂量的变化有关。对于选定的患者，鞘内注射巴氯芬可对膀胱管理方案产生有益影响。
