Foster P S, Hopkinson K C, Denborough M A
Department of Medicine and Clinical Science, John Curtin School of Medical Research, Australian National University, Canberra.
Br J Anaesth. 1989 May;62(5):560-5. doi: 10.1093/bja/62.5.560.
We have studied the ability of the calcium channel antagonist diltiazem to inhibit and reverse the porcine malignant hyperpyrexia (MH) syndrome. Pretreatment with diltiazem modified an MH response. Treatment with diltiazem was partially effective against a mild (or early) MH response. Diltiazem should not be considered to be an effective therapeutic agent for MH and should not displace the use of dantrolene.
我们研究了钙通道拮抗剂地尔硫䓬抑制和逆转猪恶性高热（MH）综合征的能力。用地尔硫䓬预处理可改变MH反应。地尔硫䓬治疗对轻度（或早期）MH反应部分有效。地尔硫䓬不应被视为治疗MH的有效药物，也不应取代丹曲林的使用。
