Harrison G G, Wright I G, Morrell D F
Department of Anaesthesia, University of Cape Town Medical School, Observatory, South Africa.
Anaesth Intensive Care. 1988 May;16(2):197-201. doi: 10.1177/0310057X8801600211.
We have investigated in malignant hyperthermia susceptible swine in vivo the effects on halothane initiation of the MH syndrome and on the established syndrome of five calcium channel blocking drugs--nifedipine, nisoldipine, diltiazem, verapamil and flunarazine. Nifedipine alone caused attenuation of halothane-initiated malignant hyperthermia to the extent of blocking onset of the syndrome in 29% of animals for the 60 minute period of exposure. In the face of the established malignant hyperthermia syndrome, all the drugs tested were therapeutically completely ineffective.
我们在恶性高热易感猪体内研究了5种钙通道阻滞剂——硝苯地平、尼索地平、地尔硫卓、维拉帕米和氟桂利嗪，对氟烷引发恶性高热综合征以及对已形成综合征的影响。仅硝苯地平就可使氟烷引发的恶性高热减弱，在60分钟的暴露期内，29%的动物可阻止该综合征的发作。面对已形成的恶性高热综合征，所有受试药物在治疗上均完全无效。
